HCSGD entry for RECQL4
1. General information
| Official gene symbol | RECQL4 |
|---|---|
| Entrez ID | 9401 |
| Gene full name | RecQ protein-like 4 |
| Other gene symbols | RECQ4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000405 | Bubble DNA binding | IDA | molecular_function |
| GO:0000733 | DNA strand renaturation | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IMP | biological_process |
| GO:0006260 | DNA replication | IDA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0032508 | DNA duplex unwinding | IDA | biological_process |
| GO:0036310 | Annealing helicase activity | IDA | molecular_function |
| GO:0043140 | ATP-dependent 3'-5' DNA helicase activity | IMP | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9412211618 | 0.0292624558 | 0.9999902473 | 0.3239605296 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1550208810 |
| GSE13712_SHEAR | Up | 0.0266736292 |
| GSE13712_STATIC | Down | -0.2629953996 |
| GSE19018 | Up | 0.1335645758 |
| GSE19899_A1 | Down | -0.1119421471 |
| GSE19899_A2 | Down | -1.0886442706 |
| PubMed_21979375_A1 | Up | 0.3560719421 |
| PubMed_21979375_A2 | Down | -0.4643426993 |
| GSE35957 | Down | -0.5472275793 |
| GSE36640 | Down | -1.3115598268 |
| GSE54402 | Down | -0.0834119219 |
| GSE9593 | Down | -0.6471359522 |
| GSE43922 | Up | 0.0569693781 |
| GSE24585 | Down | -0.0669721694 |
| GSE37065 | Down | -0.2001253360 |
| GSE28863_A1 | Down | -0.0903214943 |
| GSE28863_A2 | Up | 0.2252306666 |
| GSE28863_A3 | Up | 0.2029365913 |
| GSE28863_A4 | Up | 0.0146236934 |
| GSE48662 | Down | -0.9964611062 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016439 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039905 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24832598 | Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice |
| 24832598 | We first systematically investigated whether depletion of RECQL4 and the other four human RecQ helicases, BLM, WRN, RECQL1 and RECQL5, impacts the proliferative potential of human primary fibroblasts |
| 24832598 | We have mapped the region in RECQL4 that prevents cellular senescence to its N-terminal region and helicase domain |
| 23683351 | The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions |
| 23683351 | Oxidative DNA damage induces telomeric instability and cellular senescence that are associated with normal aging and segmental premature aging disorders such as Werner Syndrome and Rothmund-Thomson Syndrome, caused by mutations in WRN and RECQL4 helicases respectively |
| 23683351 | Characterizing the metabolic roles of RECQL4 and WRN in telomere maintenance is crucial in understanding the pathogenesis of their associated disorders |
| 23683351 | We have previously shown that WRN and RECQL4 display a preference in vitro to unwind telomeric DNA substrates containing the oxidative lesion 8-oxoguanine |
| 23683351 | Unlike that reported for telomeric D-loops containing 8-oxoguanine, RECQL4 does not cooperate with WRN to unwind telomeric D-loops with thymine glycol, suggesting RECQL4 helicase is selective for the type of oxidative lesion |
| 23683351 | RECQL4's function at the telomere is not yet understood, and our findings suggest a novel role for RECQL4 in the repair of thymine glycol lesions to promote efficient telomeric maintenance |
| 11389927 | The Saccharomyces cerevisiae SGS1 gene is a member of the RecQ family of ATP-dependent DNA helicases, which includes the human WRN, BLM and RECQ4 genes |
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