HCSGD entry for RECQL5

1. General information

Official gene symbolRECQL5
Entrez ID9400
Gene full nameRecQ protein-like 5
Other gene symbolsRECQ5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000993RNA polymerase II core bindingIDAmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003678DNA helicase activityIDA NASmolecular_function
GO:0004386Helicase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmNAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA NAScellular_component
GO:0006259DNA metabolic processNASbiological_process
GO:0006260DNA replicationIMPbiological_process
GO:0006281DNA repairIMPbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0007067MitosisIMPbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDAcellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0032508DNA duplex unwindingIDA NAS TASbiological_process
GO:0034244Negative regulation of transcription elongation from RNA polymerase II promoterIDAbiological_process
GO:0051304Chromosome separationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46397561640.95300048630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0282273614
GSE13712_SHEARUp0.1784912200
GSE13712_STATICUp0.1834438411
GSE19018Up0.0090461146
GSE19899_A1Up0.1252260776
GSE19899_A2Up0.2648538533
PubMed_21979375_A1Up0.0549706265
PubMed_21979375_A2Up0.0499809637
GSE35957Down-0.0075880359
GSE36640Up0.0155162812
GSE54402Down-0.0681689906
GSE9593Down-0.0791570955
GSE43922Up0.0419384407
GSE24585Up0.2911026061
GSE37065Up0.0008177315
GSE28863_A1Down-0.0248253767
GSE28863_A2Down-0.0262274499
GSE28863_A3Up0.1125022145
GSE28863_A4Up0.0941442645
GSE48662Up0.0113378305

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24832598We first systematically investigated whether depletion of RECQL4 and the other four human RecQ helicases, BLM, WRN, RECQL1 and RECQL5, impacts the proliferative potential of human primary fibroblasts
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