HCSGD entry for CD27

1. General information

Official gene symbolCD27
Entrez ID939
Gene full nameCD27 molecule
Other gene symbolsS152 S152. LPFS2 T14 TNFRSF7 Tp55
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004888Transmembrane signaling receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0008588Release of cytoplasmic sequestered NF-kappaBNASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010466Negative regulation of peptidase activityIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0016064Immunoglobulin mediated immune responseNASbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045579Positive regulation of B cell differentiationNASbiological_process
GO:0046330Positive regulation of JNK cascadeISSbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0052547Regulation of peptidase activityIDAbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0070233Negative regulation of T cell apoptotic processIEAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86336982260.19995630870.99999024730.8651541064

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0447059714
GSE13712_SHEARUp0.3499288202
GSE13712_STATICDown-0.0847984611
GSE19018Up0.1156749294
GSE19899_A1Up0.0232331771
GSE19899_A2Down-0.3212640579
PubMed_21979375_A1Up0.0752472762
PubMed_21979375_A2Down-0.1737053227
GSE35957Up0.1487693822
GSE36640Down-0.2053141742
GSE54402Down-0.0966686781
GSE9593Up0.0734896519
GSE43922Up0.0228676871
GSE24585Down-0.0728667948
GSE37065Down-0.0845682685
GSE28863_A1Down-0.5188891584
GSE28863_A2Down-0.8441571713
GSE28863_A3Up0.1929953120
GSE28863_A4Up0.0385055429
GSE48662Up0.1920745439

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017732MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25733583Normalization of DUSP4 expression using a specific siRNA improved CD4(+) T-cell activity in ICL, as this restored TCR-induced extracellular signal-regulated kinase activation and increased the expression of the costimulatory molecules CD27 and CD40L
25001861The classical markers of alpha/beta T cell aging, including CD28, CD27, and CD57, did not prove significant for gamma/delta T cells
25001861Although markers of aging for gamma/delta T cells are not clearly identified, our data collectively suggest that the presence of CD27 gamma/delta T cells is associated with markers of alpha/beta T cell aging
23435301Cases had lower proportions of naive T cells (CD27+ CD28+ CD45RA+) in CD4+ (23
22396780Similarly, these surface markers together with the tumor necrosis factor family member CD27 are frequently used to predict a memory T cell's ability to mount a recall response
17981205This chapter proposes that the ability of a CD8(+) T cell clone to maintain the continual production of T(EFF) during periods of persistent antigenic stimulation is based on a program that has two sequential phases of clonal expansion: an initial stage that occurs mainly in the secondary lymphoid tissues and is mediated by ligation of the T cell receptor (TCR) and CD27, and a subsequent, IL-2-dependent phase that occurs predominantly in peripheral, nonlymphoid tissues
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