HCSGD entry for NRXN1

1. General information

Official gene symbolNRXN1
Entrez ID9378
Gene full nameneurexin 1
Other gene symbolsHs.22998 PTHSL2 SCZD17
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisISSbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005102Receptor bindingISSmolecular_function
GO:0005246Calcium channel regulator activityISSmolecular_function
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIC ISScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007157Heterophilic cell-cell adhesionISSbiological_process
GO:0007158Neuron cell-cell adhesionISS TASbiological_process
GO:0007268Synaptic transmissionISSbiological_process
GO:0007269Neurotransmitter secretionIEA ISSbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007416Synapse assemblyIEA ISSbiological_process
GO:0007612LearningIMPbiological_process
GO:0009986Cell surfaceIDA ISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016339Calcium-dependent cell-cell adhesionISSbiological_process
GO:0021707Cerebellar granule cell differentiationISSbiological_process
GO:0023041Neuronal signal transductionTASbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030139Endocytic vesicleISScellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030534Adult behaviorIMPbiological_process
GO:0033130Acetylcholine receptor bindingISSmolecular_function
GO:0035176Social behaviorIMPbiological_process
GO:0035418Protein localization to synapseISSbiological_process
GO:0042297Vocal learningIMPbiological_process
GO:0042734Presynaptic membraneISS TAScellular_component
GO:0044295Axonal growth coneISScellular_component
GO:0045184Establishment of protein localizationISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048306Calcium-dependent protein bindingISSmolecular_function
GO:0050839Cell adhesion molecule bindingISSmolecular_function
GO:0050885Neuromuscular process controlling balanceIMP ISSbiological_process
GO:0051490Negative regulation of filopodium assemblyISSbiological_process
GO:0051965Positive regulation of synapse assemblyIEA ISSbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicISSbiological_process
GO:0060134Prepulse inhibitionIEAbiological_process
GO:0071625Vocalization behaviorIMPbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneISSbiological_process
GO:0090129Positive regulation of synapse maturationIEA ISSbiological_process
GO:0097091Synaptic vesicle clusteringISSbiological_process
GO:0097104Postsynaptic membrane assemblyISSbiological_process
GO:0097105Presynaptic membrane assemblyISSbiological_process
GO:0097109Neuroligin family protein bindingISSmolecular_function
GO:0097112Gamma-aminobutyric acid receptor clusteringISSbiological_process
GO:0097114N-methyl-D-aspartate receptor clusteringISSbiological_process
GO:0097116Gephyrin clusteringISSbiological_process
GO:0097117Guanylate kinase-associated protein clusteringISSbiological_process
GO:0097118Neuroligin clusteringISSbiological_process
GO:0097119Postsynaptic density protein 95 clusteringISSbiological_process
GO:0097120Receptor localization to synapseISSbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityISSbiological_process
GO:2000311Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:2000821Regulation of grooming behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70100084340.92218259940.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0295373181
GSE13712_SHEARDown-0.0003941649
GSE13712_STATICDown-0.0310788069
GSE19018Up0.0482283316
GSE19899_A1Up0.0768488155
GSE19899_A2Up0.0252603470
PubMed_21979375_A1Up0.1875554694
PubMed_21979375_A2Up0.0689467493
GSE35957Up0.0468842082
GSE36640Up0.3006918425
GSE54402Up0.0579877809
GSE9593Up0.0500214425
GSE43922Up0.0173269076
GSE24585Up0.0494330071
GSE37065Down-0.1209619588
GSE28863_A1Down-0.0064932582
GSE28863_A2Down-0.0005477748
GSE28863_A3Up0.1534642217
GSE28863_A4Up0.0036681180
GSE48662Down-0.0091906810

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT048156CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051233CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.