HCSGD entry for ZFYVE9
1. General information
| Official gene symbol | ZFYVE9 |
|---|---|
| Entrez ID | 9372 |
| Gene full name | zinc finger, FYVE domain containing 9 |
| Other gene symbols | MADHIP NSP SARA SMADIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | IDA | molecular_function |
| GO:0005769 | Early endosome | NAS | cellular_component |
| GO:0006897 | Endocytosis | NAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IMP NAS TAS | biological_process |
| GO:0007183 | SMAD protein complex assembly | IDA | biological_process |
| GO:0007184 | SMAD protein import into nucleus | IMP | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0008236 | Serine-type peptidase activity | NAS | molecular_function |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0031901 | Early endosome membrane | IDA TAS | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6024990122 | 0.1711365070 | 0.9999902473 | 0.8007971556 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0085868997 |
| GSE13712_SHEAR | Down | -0.1855422026 |
| GSE13712_STATIC | Up | 0.0840454731 |
| GSE19018 | Up | 0.1613622931 |
| GSE19899_A1 | Down | -0.2142065630 |
| GSE19899_A2 | Down | -0.0617034595 |
| PubMed_21979375_A1 | Down | -1.5627839245 |
| PubMed_21979375_A2 | Down | -0.2575155511 |
| GSE35957 | Up | 0.6531998922 |
| GSE36640 | Up | 0.3640005392 |
| GSE54402 | Down | -0.2847594624 |
| GSE9593 | Up | 0.5144973169 |
| GSE43922 | Down | -0.2663139622 |
| GSE24585 | Down | -0.2385261525 |
| GSE37065 | Down | -0.0309216564 |
| GSE28863_A1 | Up | 0.0010261538 |
| GSE28863_A2 | Down | -0.2075695294 |
| GSE28863_A3 | Up | 0.0443268055 |
| GSE28863_A4 | Down | -0.0939608055 |
| GSE48662 | Up | 0.5118033445 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT039606 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046751 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15356634 | Furthermore, cytoplasmic PML physically interacts with Smad2/3 and SARA (Smad anchor for receptor activation) and is required for association of Smad2/3 with SARA and for the accumulation of SARA and TGF-beta receptor in the early endosome |
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