HCSGD entry for ADIPOQ

1. General information

Official gene symbolADIPOQ
Entrez ID9370
Gene full nameadiponectin, C1Q and collagen domain containing
Other gene symbolsACDC ACRP30 ADIPQTL1 ADPN APM-1 APM1 GBP28
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0005102Receptor bindingISSmolecular_function
GO:0005125Cytokine activityNASmolecular_function
GO:0005179Hormone activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005581CollagenIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0006006Glucose metabolic processISSbiological_process
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006635Fatty acid beta-oxidationISSbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0009744Response to sucroseIEAbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0009967Positive regulation of signal transductionISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0010739Positive regulation of protein kinase A signalingIDAbiological_process
GO:0010745Negative regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0010875Positive regulation of cholesterol effluxIDAbiological_process
GO:0010906Regulation of glucose metabolic processIDAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0014912Negative regulation of smooth muscle cell migrationIDAbiological_process
GO:0019395Fatty acid oxidationISSbiological_process
GO:0030336Negative regulation of cell migrationISSbiological_process
GO:0030853Negative regulation of granulocyte differentiationIDAbiological_process
GO:0031953Negative regulation of protein autophosphorylationIDAbiological_process
GO:0032270Positive regulation of cellular protein metabolic processIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0033034Positive regulation of myeloid cell apoptotic processIDAbiological_process
GO:0033211Adiponectin-activated signaling pathwayIEAbiological_process
GO:0033691Sialic acid bindingIDAmolecular_function
GO:0034115Negative regulation of heterotypic cell-cell adhesionIDAbiological_process
GO:0034383Low-density lipoprotein particle clearanceIDAbiological_process
GO:0034612Response to tumor necrosis factorIDAbiological_process
GO:0035690Cellular response to drugISSbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042802Identical protein bindingTASmolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingISSbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043407Negative regulation of MAP kinase activityISSbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045599Negative regulation of fat cell differentiationIDAbiological_process
GO:0045650Negative regulation of macrophage differentiationIDAbiological_process
GO:0045715Negative regulation of low-density lipoprotein particle receptor biosynthetic processIDAbiological_process
GO:0045721Negative regulation of gluconeogenesisISSbiological_process
GO:0045776Negative regulation of blood pressureIDAbiological_process
GO:0045777Positive regulation of blood pressureIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045923Positive regulation of fatty acid metabolic processISSbiological_process
GO:0046326Positive regulation of glucose importISSbiological_process
GO:0046888Negative regulation of hormone secretionIEAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050728Negative regulation of inflammatory responseISS NASbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050765Negative regulation of phagocytosisIDAbiological_process
GO:0050805Negative regulation of synaptic transmissionIDAbiological_process
GO:0050873Brown fat cell differentiationISSbiological_process
GO:0051260Protein homooligomerizationISSbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051899Membrane depolarizationIEAbiological_process
GO:0060081Membrane hyperpolarizationIEAbiological_process
GO:0070208Protein heterotrimerizationIEAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070543Response to linoleic acidIEAbiological_process
GO:0070994Detection of oxidative stressISSbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071639Positive regulation of monocyte chemotactic protein-1 productionIDAbiological_process
GO:0071872Cellular response to epinephrine stimulusIEAbiological_process
GO:0072659Protein localization to plasma membraneIDAbiological_process
GO:0090317Negative regulation of intracellular protein transportIDAbiological_process
GO:1900121Negative regulation of receptor bindingIDAbiological_process
GO:2000279Negative regulation of DNA biosynthetic processIDAbiological_process
GO:2000467Positive regulation of glycogen (starch) synthase activityISSbiological_process
GO:2000478Positive regulation of metanephric glomerular visceral epithelial cell developmentISSbiological_process
GO:2000481Positive regulation of cAMP-dependent protein kinase activityIDAbiological_process
GO:2000534Positive regulation of renal albumin absorptionIDAbiological_process
GO:2000584Negative regulation of platelet-derived growth factor receptor-alpha signaling pathwayISSbiological_process
GO:2000590Negative regulation of metanephric mesenchymal cell migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46745214090.48043481630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4932568259
GSE13712_SHEARUp0.1149771626
GSE13712_STATICDown-0.0292597141
GSE19018Up0.0543868683
GSE19899_A1Up0.2637751785
GSE19899_A2Down-0.0297165873
PubMed_21979375_A1Down0.0000000000
PubMed_21979375_A2Down-0.0425761789
GSE35957Up0.3630647792
GSE36640Down-0.0700980798
GSE54402Down-0.0810265597
GSE9593Down-2.4609378359
GSE43922Up0.0140074274
GSE24585Down-0.0360195170
GSE37065Up0.0045571914
GSE28863_A1Down-0.0938883697
GSE28863_A2Down-0.0873925200
GSE28863_A3Up0.0655266380
GSE28863_A4Up0.0416742152
GSE48662Up0.0085746745

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 14 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27349869Adiponectin corrects premature cellular senescence and normalizes antimicrobial peptide levels in senescent keratinocytes
27349869Acrp30 stimulation reduced the premature senescence positive ratio induced by hydrogen peroxide (H2O2) and restituted human beta-defensin 2 (hBD-2) levels in senescent keratinocytes
27349869Additionally, Acrp30 stimulation suppresses NFkappaB p65, which induces abnormal expression of hBD-2 induced by H2O2
27349869In the present study, we have shown that Acrp30 reduces premature senescence and recovers cellular function in keratinocytes
27349869These results suggest a role for Acrp30 as an anti-aging agent to improve impaired skin immune barriers
27228653This is associated with a complete inhibition of the expression of adipogenic marker genes--PPARgamma2, ADIPOQ and a decrease in the expression of RB, p130, but not UTX
27092462Adiponectin induces CXCL1 secretion from cancer cells and promotes tumor angiogenesis by inducing stromal fibroblast senescence
27092462Adiponectin is an adipocyte-specific adipocytokine with proliferative and pro-angiogenic effects that regulates many biological processes, including immunity, insulin resistance, and inflammation
27092462The oncogenic role of adiponectin has been implicated in several cancer types
27092462Stromal cells within tumor contribute tumor growth and angiogenesis; however, it is not clear that how adiponectin regulates stromal cell-mediated tumorigenesis
27092462In this study, using the tumor xenograft models, we demonstrated that tumor development was severely impaired in mouse subcutaneous cancer tissue and metastasis tumor tissue in adiponectin knockout mice
27092462Our results indicated adiponectin deficiency resulted in decrease of blood vessel and stromal senescent fibroblasts in subcutaneous and metastasis tumor tissue
27092462These observations were confirmed in vitro, in which co-cultured tumor cells and fibroblasts treated with adiponectin promoted ECs tube formation
27092462Taken together, our results indicate that adiponectin promotes stromal cell senescence within invasive colon cancer contributing to angiogenesis and tumor growth in part through the production of CXCL1 and may serve as a therapeutic target for tumor patients
26380096Biomarkers of obesity (leptin, adiponectin), diabetes (glucose, insulin), inflammation (C-reactive protein, Interleukin-6, surface tumor necrosis factor receptor (sTNFR) I & II) and oxidative stress (F2-isoprostanes) were measured in stored blood samples
25526565Finally, it also acts as a cellular adapter, interacting with the N-terminal domain of adiponectin receptor
24030923Adipokines liberated from adipose tissues play roles in modulating endothelial function; adiponectin and ghrelin have beneficial effects on endothelial cells
23849162Low serum levels of sex-hormone binding globulin and adiponectin suggested a post-receptor insulin signalling defect
23657974Furthermore, the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired
23385819Senescent cells were also characterized by decreased levels of adiponectin and impaired glucose uptake
21660946This was accompanied by respective gene expression changes of some adipogenic key molecules (adiponectin and fatty acid-binding protein 4 [FABP4])
21439968Globular adiponectin improves high glucose-suppressed endothelial progenitor cell function through endothelial nitric oxide synthase dependent mechanisms
21439968Plasma levels of adiponectin, an adipose-specific protein with putative anti-atherogenic properties, could be down-regulated in obese and diabetic subjects
21439968Here, we tested the hypothesis that globular adiponectin can improve high glucose-suppressed EPC functions by restoration of endothelial nitric oxide synthase (eNOS) activity
21439968EPCs were incubated with high glucose (25 mM) and treatment with globular adiponectin for functional study
21439968Administration of globular adiponectin at physiological concentrations promoted EPC migration and tube formation, and dose-dependently upregulated phosphorylation of eNOS, Akt and augmented NO production
21439968Chronic incubation of EPCs in high-glucose medium significantly impaired EPC function and induced cellular senescence, but these suppression effects were reversed by treatment with globular adiponectin
21439968In addition, nude mice that received EPCs treated with adiponectin in high glucose medium showed a significant improvement in blood flow than those received normal saline and EPCs incubated in high glucose conditions
21439968The administration of globular adiponectin improved high glucose-impaired EPC functions in vasculogenesis by restoration of eNOS activity
21439968These beneficial effects may provide some novel rational to the vascular protective properties of adiponectin
20380516Data also evidenced that high glucose concentrations cause prominent disparities in nASCs and dASCs in expression of genes involved in insulin resistance such as adiponectin and resistin
19526322The mRNA levels and secretion of adiponectin, quickly rose as adipocytes matured and then declined
19526322LPS decreased the mRNA levels of C/EBPalpha and PPARgamma at all time points, as well as those of GLUT4, IRS-1 and adiponectin
19526322These data suggest that aging adipocytes in vitro show a decline in pro-adipogenic signals, in genes involved in glucose metabolism and cytoskeleton maintenance and in adiponectin
14625202Moreover, aged adipocytes show reduced gene expression for adiponectin and leptin, each of which is important in systemic regulation of energy metabolism
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