HCSGD entry for KL
1. General information
| Official gene symbol | KL |
|---|---|
| Entrez ID | 9365 |
| Gene full name | klotho |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002526 | Acute inflammatory response | IEA | biological_process |
| GO:0004553 | Hydrolase activity, hydrolyzing O-glycosyl compounds | IEA | molecular_function |
| GO:0004566 | Beta-glucuronidase activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005104 | Fibroblast growth factor receptor binding | IEA | molecular_function |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005499 | Vitamin D binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA | biological_process |
| GO:0006112 | Energy reserve metabolic process | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007568 | Aging | IEA IMP | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IEA TAS | biological_process |
| GO:0008422 | Beta-glucosidase activity | TAS | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | IEA TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA TAS | cellular_component |
| GO:0017134 | Fibroblast growth factor binding | IPI | molecular_function |
| GO:0030501 | Positive regulation of bone mineralization | IMP | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0055074 | Calcium ion homeostasis | IEA | biological_process |
| GO:0090080 | Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5625613654 | 0.5891894571 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3423277217 |
| GSE13712_SHEAR | Up | 0.0735581315 |
| GSE13712_STATIC | Up | 0.2789105281 |
| GSE19018 | Up | 0.3329431959 |
| GSE19899_A1 | Down | -0.0758368733 |
| GSE19899_A2 | Down | -0.2244342032 |
| PubMed_21979375_A1 | Down | -0.0981635980 |
| PubMed_21979375_A2 | Up | 0.1996644046 |
| GSE35957 | Down | -0.0901321664 |
| GSE36640 | Up | 0.1814381707 |
| GSE54402 | Down | -0.1774372803 |
| GSE9593 | Down | -0.2911364817 |
| GSE43922 | Up | 0.0116557312 |
| GSE24585 | Up | 0.1023377660 |
| GSE37065 | Up | 0.0563901387 |
| GSE28863_A1 | Down | -0.2670628004 |
| GSE28863_A2 | Down | -0.0440865301 |
| GSE28863_A3 | Up | 0.0693890302 |
| GSE28863_A4 | Up | 0.0822346741 |
| GSE48662 | Down | -0.0753209806 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019099 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 35 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27885332 | 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside Promotes Expression of the Longevity Gene Klotho |
| 27885332 | The longevity gene klotho has numerous physiological functions, such as regulating calcium and phosphorus levels, delaying senescence, improving cognition, reducing oxidative stress, and protecting vascular endothelial cells |
| 27885332 | Our results showed that THSG dose-dependently increased the luciferase reporter activity of the klotho gene, reversed the decrease in mRNA and protein expression of klotho which was induced by angiotensin II in NRK-52E renal tubular epithelial cells, and increased klotho mRNA expression in the cerebral cortex, hippocampus, testis, and kidney medulla of spontaneously hypertensive rats |
| 27885332 | Based on klotho's role in promoting cognition, regulating bone metabolism, and improving renal function, the effect of THSG on klotho expression will be beneficial to the functional improvement or enhancement of the expressed organs or tissues |
| 27313833 | Corrigendum to "Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression" |
| 27125746 | Alpha-Klotho (alphaKlotho) protein is encoded by the gene, Klotho, and functions as a coreceptor for endocrine fibroblast growth factor-23 |
| 26797283 | The MSCs expressed FGF receptors (1 through 4) and angiotensin-II type 1 receptor, but no traces of the Klotho gene were detected |
| 26583057 | Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression |
| 26583057 | In this work, we were searching for novel intermediaries in oxidative stress-induced senescence, focusing our interest on integrin-linked kinase (ILK), a scaffold protein at cell-extracellular matrix (ECM) adhesion sites, and on the Klotho gene |
| 26583057 | Additionally, GOx reduced Klotho gene expression and cells overexpressing Klotho protein did not undergo senescence after GOx addition |
| 26583057 | We demonstrated a direct link between ILK and Klotho since silencing ILK expression in cells and mice increases Klotho expression and reduces p53 and p16 expression in renal cortex |
| 26583057 | In conclusion, oxidative stress induces cellular senescence in kidney cells by increasing ILK protein expression and activity, which in turn reduces Klotho expression |
| 26583057 | We hereby present ILK as a novel downregulator of Klotho gene expression |
| 26528423 | Biological Role of Anti-aging Protein Klotho |
| 26528423 | Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan |
| 26528423 | Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation |
| 26528423 | Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases |
| 26528423 | The three forms of Klotho protein have distinct functions |
| 26528423 | Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism |
| 26528423 | Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis |
| 26528423 | Secreted Klotho is also involved in organ protection |
| 26528423 | Herein we provide a brief overview of the structure and function and recent research about Klotho |
| 26346243 | Klotho, stem cells, and aging |
| 26346243 | Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, such as antioxidation, antisenescence, antiautophagy, and modulation of many signaling pathways, including insulin-like growth factor and Wnt |
| 26346243 | Klotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis |
| 26346243 | In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells |
| 26346243 | A better understanding of the potential effects of klotho on stem cells could offer novel insights into the cellular and molecular mechanisms of klotho deficiency-related aging and disease |
| 26346243 | The klotho protein may be a promising therapeutic agent for aging and aging-related disorders |
| 26100223 | Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells |
| 26100223 | The anti-aging gene, klotho, encodes a membrane bound protein that has been shown to be a key regulator of oxidative stress and cellular senescence |
| 26100223 | In this study the role of Klotho (KL) with regard to oxidative stress and cellular senescence was investigated in human pulmonary epithelial cells exposed to cigarette smoke |
| 26100223 | Individual clones that stably overexpress Klotho were generated through retroviral transfection and geneticin selection |
| 26100223 | Klotho overexpression was confirmed through RT-qPCR, Western blotting and ELISA |
| 26100223 | Compared to control cells, constitutive Klotho overexpression resulted in decreased sensitivity to cigarette smoke induced cell death in vitro via a reduction of reactive oxygen species and a decrease in the expression of p21 |
| 25923845 | Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice |
| 25614163 | There is also a reduction in anti-ageing molecules, such as sirtuins and Klotho, which further accelerates the ageing process |
| 25246106 | Klotho Prevents NFkappaB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia |
| 25246106 | Klotho protein is a beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides |
| 25246106 | The aim of the study was to investigate how senescence and oxidative stress induced by uremia in endothelial cells affects Klotho expression and whether intra or extracellular Klotho has effects on the response of these cells |
| 25246106 | The expression of Klotho decreased with the uremia and preceded the manifestations of cell aging |
| 25246106 | Levels of intracellular Klotho decreases associated to endothelial senescence, and exogenous Klotho prevents cellular senescence by inhibiting the increase in oxidative stress induced by uremia and diminished the nuclear factor kappa B-DNA binding ability |
| 24778222 | PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice |
| 24778222 | Klotho functions as an aging-suppressor gene, and Klotho-deficient (kl/kl) mice exhibit an accelerated aging-like phenotype that includes a truncated lifespan, arteriosclerosis, and emphysema |
| 23666415 | FGF23 and Klotho in chronic kidney disease |
| 23666415 | PURPOSE OF REVIEW: The wealth of data regarding fibroblast growth factor-23 (FGF23) and Klotho in chronic kidney disease (CKD) has risen exponentially over the past decade |
| 23666415 | Identification of contributing stimuli to the rise in FGF23 is fundamental and recent evidence suggest a multifactorial cause which entails perturbed osteocyte function and renal mechanisms such as Klotho deficiency and, somewhat paradoxically, systemic Klotho excess |
| 23666415 | Conversely, tissue level of the FGF23 coreceptor Klotho declines in early CKD and this deficiency is linked to accelerated ageing, cellular senescence, vascular calcification, oxidative stress and renal fibrosis |
| 23666415 | At present, methodological difficulties limit the utility of soluble Klotho measurements |
| 23666415 | Animal proof-of-concept studies have demonstrated beneficial effects of Klotho delivery in CKD, whereas anti-FGF23 therapy using neutralizing antibodies improved biochemical and bone parameters at the expense of increased vascular calcification and mortality |
| 23357108 | This occurs through several mechanisms, including DNA and mitochondria damage, increased reactive oxygen species generation, persistent inflammation, stem cell exhaustion, phosphate toxicity, decreased klotho expression, and telomere attrition |
| 23357108 | Because recent evidence suggests that both increased local signaling of growth factors (through the nutrient-sensing mammalian target of rapamycin) and decreased klotho expression are important modulators of aging, interventions that target these should be tested in this prematurely aged population |
| 23041151 | The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice |
| 23041151 | Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes |
| 23041151 | Furthermore, transgenic overexpression of klotho in mice extends their life span through inhibition of insulin and IGF1 signaling |
| 23041151 | We found that intraperitoneal injection of recombinant soluble Klotho protein at dose of 0 |
| 23041151 | Soluble Klotho administration also ameliorated premature aging-related phenotype, such as growth retardation, premature thymus involution and vascular calcification, and effectively enhanced urinary phosphate excretion in kl/kl mice |
| 23041151 | Klotho treatment attenuated renal fibrosis through down-regulation of transforming growth factor-beta signaling as well as reduced cellular senescence through down-regulation of p21-cip1 mRNA levels |
| 23041151 | In addition, soluble Klotho treatment significantly reduced both renal and aorta calcium deposits |
| 23041151 | In conclusion, our study shows the therapeutic potential of soluble Klotho protein to treat age-related disorders in mice |
| 23000105 | Klotho modulates the stress response in human senescent endothelial cells |
| 23000105 | Lack of Klotho expression in mice leads to premature aging and age-related diseases, including vascular diseases |
| 23000105 | The aim of this study was to determine how endothelial cell line senescence affects Klotho expression and whether intra- or extracellular Klotho has any effect on the response of senescent cells to oxidative stress |
| 23000105 | The decline in Klotho preceded the manifestations of cell ageing: telomere shortening and beta-galactosidase expression |
| 23000105 | Klotho was also reduced in cells exposed to the proinflammatory cytokine TNFalpha |
| 23000105 | The addition of exogenous Klotho to aging cells did not modify the proportion of cells with short telomeres or any other feature of cell aging; however, exogenous Klotho prevented the changes resembling premature cellular senescence associated with TNFalpha, such as the decrease in telomere length and the increase in beta-galactosidase-positive cells |
| 23000105 | Likewise exogenous Klotho prevented the increases in reactive oxygen species (ROS) activity, mitochondrial potential and cell apoptosis induced by TNFalpha |
| 22242193 | 1,25-dihydroxyvitamin D3 (1,25D3) was reported to induce premature organismal aging in fibroblast growth factor-23 (Fgf23) and klotho deficient mice, which is of main interest as 1,25D3 supplementation of its precursor cholecalciferol is used in basic osteoporosis treatment |
| 22200425 | Administration of indoxyl sulfate to hypertensive rats reduces renal expression of Klotho and promotes cell senescence, with expression of senescence-associated beta-galactosidase, p53, p21, p16, and retinoblastoma protein, accompanied by kidney fibrosis |
| 22200425 | Indoxyl sulfate downregulates Klotho expression in the kidneys through production of ROS and activation of nuclear factor kappa B in proximal tubular cells |
| 21965376 | Young-to-old mice also exhibited higher expression of the anti-aging gene Klotho and less phosphorylation of IGF-1 receptor beta |
| 21518171 | Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway |
| 21518171 | AIM: Mice that carry the Klotho mutation (KL(-) (/) (-) ) manifest diverse age-related disorders similar to those observed in humans |
| 21518171 | Thus, the Klotho protein might function as an anti-aging hormone in mammals |
| 21518171 | Recently, we reported that Klotho recombinant protein attenuated apoptosis and cellular senescence in endothelial cells, but the mechanism remained unclear |
| 21518171 | Here, we designed an in vitro study to test whether inhibitors of extracellular signal-regulated kinase and mitogen-activated kinase kinase could affect Klotho regulation of apoptosis and cellular senescence |
| 21518171 | METHODS: Cellular senescence was investigated in human umbilical vein endothelial cells treated with or without Klotho recombinant protein, and with or without inhibitors of mitogen-activated kinases |
| 21518171 | RESULTS: The Klotho recombinant protein induced transient phosphorylation of mitogen-activated kinases within a few minutes |
| 21518171 | Application of inhibitors of mitogen-activated kinases attenuated the ability of Klotho to interfere with apoptosis and senescence in endothelial cells |
| 21358327 | SUMMARY: Here we review recent advances in understanding the role of Klotho, sirtuins, cell senescence through oxidative stress and mitochondrial dysfunction, as well as of the renin-angiotensin system in modulating age-related kidney damage |
| 21336305 | Klotho has been associated with ageing |
| 21336305 | We show here that the intracellular, but not the secreted, form of klotho interacts with RIG-I and that this interaction inhibits RIG-I-induced expression of IL-6 and IL-8 both in vitro and in vivo |
| 21336305 | Our study uncovers a mechanism in which klotho functions as an anti-ageing factor through the suppression of RIG-I-mediated inflammation |
| 21235497 | This review discusses the molecular mechanisms of cellular senescence and its affect on calcification of vascular cells, the relevance of phosphate regulation and the function of FGF23 and Klotho proteins |
| 21195930 | Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats |
| 21195930 | Klotho, an anti-aging gene, is expressed in the kidneys, and its renal expression is decreased in chronic kidney disease |
| 21195930 | This study aimed to clarify whether indoxyl sulfate could reduce klotho expression and contribute to cell senescence in the kidneys of hypertensive rats |
| 21195930 | Further, DN + IS rats showed decreased expression of klotho as compared with DN rats |
| 20832068 | Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression |
| 20716932 | Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence |
| 20716932 | Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors which are stimulated by ROS signaling |
| 19955715 | An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats |
| 19797472 | Underlying mechanisms included increased expression of klotho, decreased systemic and renal oxidative stress, and decreased mitochondrial injury |
| 19749165 | Furthermore, immunohistochemistry of aorta from the klotho(-/-) aging mouse model demonstrated in vivo emergence of osteoblast-like cells expressing RUNX-2 exclusively in the calcified media |
| 17690294 | We explored this concept in the Klotho mouse model of accelerated aging |
| 17690294 | Analysis of various tissues and organs from young Klotho mice revealed a decrease in stem cell number and an increase in progenitor cell senescence |
| 17690294 | Because klotho is a secreted protein, we postulated that klotho might interact with other soluble mediators of stem cells |
| 17690294 | We found that klotho bound to various Wnt family members |
| 17690294 | Tissues and organs from klotho-deficient animals showed evidence of increased Wnt signaling, and ectopic expression of klotho antagonized the activity of endogenous and exogenous Wnt |
| 17690294 | Thus, klotho appears to be a secreted Wnt antagonist and Wnt proteins have an unexpected role in mammalian aging |
| 17202338 | Here we show that KLOTHO, a beta-glucuronidase gene whose activity changes are associated with aging phenotype, is down-regulated at the mRNA, protein, and enzymatic (beta-glucuronidase) activity levels both in the healthy elderly and especially in RA CD4(+) lymphocytes |
| 17202338 | Although the exact role of Klotho activity for CD4(+) cell function is unknown, we propose here that it might be involved in anti-inflammatory processes occurring in the young and healthy individuals, but reduced in both healthy elderly and RA patients |
| 17202338 | To support this hypothesis, we show here that the reduction of Klotho expression and activity in both elderly and patients' lymphocytes occurs in concert with the down-regulation of T cell costimulatory molecule CD28, the latter known to be dependent on increased levels of TNF-alpha |
| 17202338 | Thus, a common mechanism of KLOTHO down-regulation, but executed at various times in life, may underlie both physiological and disease-related T cell aging |
| 17202338 | Klotho activity might become a target of anti-RA drug development as well as a tool to help increase the immune system efficiency in the elderly |
| 17014852 | Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway |
| 17014852 | Klotho has recently emerged as a regulator of aging |
| 17014852 | To investigate the role of Klotho in the regulation of cellular senescence, we generated stable MRC-5 human primary fibroblast cells knockdown for Klotho expression by RNAi |
| 17014852 | Downregulation of Klotho dramatically induces premature senescence with a concomitant upregulation of p21 |
| 17014852 | Knockdown of p53 in the Klotho attenuated MRC-5 cells restores normal growth and replicative potential |
| 17014852 | These results demonstrate that Klotho normally regulates cellular senescence by repressing the p53/p21 pathway |
| 17014852 | Our findings implicate Klotho as a regulator of aging in primary human fibroblasts |
| 16325773 | Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells |
| 16325773 | A recent study suggested that Klotho protein might function as an anti-aging hormone in mammals |
| 16325773 | Klotho overexpression decreased H(2)O(2)-induced apoptosis in COS-1 cells and Jurkat cells |
| 16325773 | Klotho protein also reduced H(2)O(2)- and etoposide-induced apoptosis in HUVEC |
| 16325773 | Senescence-associated beta-gal staining showed that Klotho protein interferes with H(2)O(2)-induced premature cellular senescence |
| 16325773 | Our study suggests that Klotho acts as a humoral factor to reduce H(2)O(2)-induced apoptosis and cellular senescence in vascular cells |
| 15339392 | Establishment of a cell-based assay to screen regulators for Klotho gene promoter |
| 15339392 | AIM: To discover compounds which can regulate Klotho promoter activity |
| 15339392 | Klotho is an aging suppressor gene |
| 15339392 | A defect in Klotho gene expression in the mouse results in the phenotype similar to human aging |
| 15339392 | Recombinant Klotho protein improves age-associated diseases in animal models |
| 15339392 | It has been proposed that up-regulation of Klotho gene expression may have anti-aging effects |
| 15339392 | METHODS: Klotho promoter was cloned into a vector containing luciferase gene, and the reporter gene vector was transfected into HEK293 cells to make a stable cell line (HEK293/KL) |
| 15339392 | The luciferase activity was detected to identify compounds that can regulate Klotho promoter |
| 15339392 | RESULTS: The expression of luciferase in these cells was under control of Klotho promoter and down-regulated after H2O2 treatment |
| 15339392 | This result demonstrated that the Klotho gene promoter was regulated by oxidative stress |
| 15339392 | Using the cell-based reporter gene assay, we screened natural product extracts for regulation of Klotho gene promoter |
| 15339392 | Several extracts were identified that could rescue the H2O2 effects and up-regulated Klotho promoter activity |
| 15339392 | CONCLUSION: A cell -based assay for high-throughput drug screening was established to identify compounds that regulate Klotho promoter activity, and several hits were discovered from natural products |
| 15339392 | Further characterization of these active extracts could help to investigate Klotho function and aging mechanisms |
| 14653227 | Klotho is a recently identified gene that is a very different type from those involved in previously described premature-aging syndromes and cell senescence |
| 14653227 | Although a high level of expression of the klotho gene was detected in the kidney and brain, little is known about the function of the klotho gene in the brain |
| 14653227 | Here we investigated the changes in mnemonic function accompanying aging in klotho mutant mice |
| 14653227 | Cognitive function measured by novel-object recognition and conditioned-fear tests in klotho mutant mice was normal at the age of 6 weeks, but markedly impaired at the age of 7 weeks |
| 14653227 | Lipid peroxide (malondialdehyde) and DNA peroxide (8-hydroxy-2'-deoxyguanosine) levels in the hippocampus of klotho mutant mice increased at the age of 5 weeks, 2 weeks prior to the development of cognition deficits |
| 14653227 | Pro-death Bax increased, while anti-death Bcl-2 and Bcl-XL decreased, and apoptotic TUNEL-positive cells were detected in the hippocampus of klotho mutant mice at the age of 7 weeks |
| 14653227 | A potent antioxidant alpha-tocopherol prevented the cognition impairment and lipid peroxide accumulation, and decreased the number of apoptotic cells in klotho mutant mice |
| 14653227 | These results suggest that oxidative stress has a crucial role in the aging-associated cognition impairment in klotho mutant mice |
| 14653227 | Klotho protein may be involved in the regulation of antioxidative defense |
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