HCSGD entry for LHX2
1. General information
| Official gene symbol | LHX2 |
|---|---|
| Entrez ID | 9355 |
| Gene full name | LIM homeobox 2 |
| Other gene symbols | LH2 hLhx2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001076 | RNA polymerase II transcription factor binding transcription factor activity | IEA | molecular_function |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0007498 | Mesoderm development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009953 | Dorsal/ventral pattern formation | IEA | biological_process |
| GO:0021772 | Olfactory bulb development | IEA | biological_process |
| GO:0021978 | Telencephalon regionalization | IEA | biological_process |
| GO:0021987 | Cerebral cortex development | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:2000678 | Negative regulation of transcription regulatory region DNA binding | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5303575814 | 0.9180128453 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2642115334 |
| GSE13712_SHEAR | Down | -0.0743332987 |
| GSE13712_STATIC | Down | -0.0592009272 |
| GSE19018 | Up | 0.1748835209 |
| GSE19899_A1 | Up | 0.1381157832 |
| GSE19899_A2 | Up | 0.0936017873 |
| PubMed_21979375_A1 | Up | 0.1685591061 |
| PubMed_21979375_A2 | Up | 0.1351753271 |
| GSE35957 | Down | -0.1557987872 |
| GSE36640 | Up | 0.1730139984 |
| GSE54402 | Up | 0.0210810663 |
| GSE9593 | Down | -0.0537434360 |
| GSE43922 | Up | 0.0320432852 |
| GSE24585 | Up | 0.1054118996 |
| GSE37065 | Down | -0.0496100430 |
| GSE28863_A1 | Down | -0.0259918959 |
| GSE28863_A2 | Down | -0.0556854052 |
| GSE28863_A3 | Up | 0.1383657113 |
| GSE28863_A4 | Up | 0.0273899505 |
| GSE48662 | Down | -0.0445222862 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022169 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042689 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
