HCSGD entry for SLIT2

1. General information

Official gene symbolSLIT2
Entrez ID9353
Gene full nameslit homolog 2 (Drosophila)
Other gene symbolsSLIL3 Slit-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001656Metanephros developmentIEAbiological_process
GO:0001657Ureteric bud developmentIMPbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisIMPbiological_process
GO:0002689Negative regulation of leukocyte chemotaxisIDAbiological_process
GO:0005095GTPase inhibitor activityIDAmolecular_function
GO:0005509Calcium ion bindingIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007411Axon guidanceIDA TASbiological_process
GO:0008045Motor neuron axon guidanceIDAbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010593Negative regulation of lamellipodium assemblyIDAbiological_process
GO:0010596Negative regulation of endothelial cell migrationIDAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0014912Negative regulation of smooth muscle cell migrationIDAbiological_process
GO:0016020MembraneNAScellular_component
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0021834Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationIDAbiological_process
GO:0021836Chemorepulsion involved in postnatal olfactory bulb interneuron migrationIDAbiological_process
GO:0021972Corticospinal neuron axon guidance through spinal cordIMPbiological_process
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0030336Negative regulation of cell migrationIDA IMPbiological_process
GO:0030837Negative regulation of actin filament polymerizationIDAbiological_process
GO:0031290Retinal ganglion cell axon guidanceIDAbiological_process
GO:0032870Cellular response to hormone stimulusIEPbiological_process
GO:0033563Dorsal/ventral axon guidanceIEAbiological_process
GO:0035385Roundabout signaling pathwayIC IMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043116Negative regulation of vascular permeabilityIDAbiological_process
GO:0043237Laminin-1 bindingIDAmolecular_function
GO:0043394Proteoglycan bindingIPImolecular_function
GO:0045499Chemorepellent activityIEAmolecular_function
GO:0048495Roundabout bindingIPImolecular_function
GO:0048754Branching morphogenesis of an epithelial tubeIDA IMPbiological_process
GO:0048846Axon extension involved in axon guidanceIDAbiological_process
GO:0050772Positive regulation of axonogenesisTASbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0050919Negative chemotaxisIDA IMPbiological_process
GO:0050929Induction of negative chemotaxisIDAbiological_process
GO:0051058Negative regulation of small GTPase mediated signal transductionIDAbiological_process
GO:0051414Response to cortisolIEPbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0061364Apoptotic process involved in luteolysisIEPbiological_process
GO:0070100Negative regulation of chemokine-mediated signaling pathwayIMPbiological_process
GO:0071504Cellular response to heparinIDAbiological_process
GO:0071672Negative regulation of smooth muscle cell chemotaxisIDAbiological_process
GO:0071676Negative regulation of mononuclear cell migrationIDAbiological_process
GO:0090024Negative regulation of neutrophil chemotaxisIDAbiological_process
GO:0090027Negative regulation of monocyte chemotaxisISSbiological_process
GO:0090260Negative regulation of retinal ganglion cell axon guidanceIDAbiological_process
GO:0090288Negative regulation of cellular response to growth factor stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24884523000.00021042890.93718759830.0256421296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4088502960
GSE13712_SHEARUp0.0183743370
GSE13712_STATICUp0.0840019811
GSE19018Down-2.0493272824
GSE19899_A1Down-0.2094867067
GSE19899_A2Down-2.8202802028
PubMed_21979375_A1Down-3.2857305424
PubMed_21979375_A2Down-3.9790250472
GSE35957Down-2.1014552447
GSE36640Down-2.8598547620
GSE54402Down-1.9914502180
GSE9593Up0.3974212348
GSE43922Down-1.3028132921
GSE24585Down-0.5741522370
GSE37065Up0.3867401894
GSE28863_A1Up1.3912724946
GSE28863_A2Up1.0892860562
GSE28863_A3Down-0.3303420301
GSE28863_A4Down-0.3300722525
GSE48662Up0.3311222062

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-330-3pMIMAT0000751MIRT043835CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26047956Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence
26047956Our results showed that the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes, there was gradual increase in cell viability along with restoration of the expression of Topo IIbeta and potential repair proteins
25241737Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling
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