HCSGD entry for CNOT8

1. General information

Official gene symbolCNOT8
Entrez ID9337
Gene full nameCCR4-NOT transcription complex, subunit 8
Other gene symbolsCAF1 CALIF POP2 hCAF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityIDAmolecular_function
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0004535Poly(A)-specific ribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005634NucleusIEA NAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0030014CCR4-NOT complexIDAcellular_component
GO:0035195Gene silencing by miRNATASbiological_process
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDAbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDAbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04331512100.67580357130.46326586751.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2369772346
GSE13712_SHEARUp0.0285840837
GSE13712_STATICDown-0.3183276936
GSE19018Up0.7861734334
GSE19899_A1Up0.5239683006
GSE19899_A2Up0.6558289312
PubMed_21979375_A1Up0.8629895222
PubMed_21979375_A2Up0.3967342819
GSE35957Down-0.3641577507
GSE36640Down-0.0247615587
GSE54402Up0.3507363348
GSE9593Down-0.1700437973
GSE43922Up0.6242457082
GSE24585Up0.4224056506
GSE37065Up0.1940689312
GSE28863_A1Down-0.0663275074
GSE28863_A2Up0.2112937645
GSE28863_A3Down-0.4966988841
GSE28863_A4Down-0.1190984324
GSE48662Down-0.4812103727

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT004058Microarray//Microarray;OtherFunctional MTI (Weak)19073608
hsa-miR-7-5pMIMAT0000252MIRT004058SequencingFunctional MTI (Weak)20371350
hsa-miR-504-5pMIMAT0002875MIRT041088CLASHFunctional MTI (Weak)23622248
hsa-let-7f-5pMIMAT0000067MIRT051367CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.