HCSGD entry for GTF3C4
1. General information
| Official gene symbol | GTF3C4 |
|---|---|
| Entrez ID | 9329 |
| Gene full name | general transcription factor IIIC, polypeptide 4, 90kDa |
| Other gene symbols | KAT12 TFIII90 TFIIIC290 TFIIIC90 TFIIICDELTA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000127 | Transcription factor TFIIIC complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IC | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IC | biological_process |
| GO:0006383 | Transcription from RNA polymerase III promoter | IC TAS | biological_process |
| GO:0006384 | Transcription initiation from RNA polymerase III promoter | TAS | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016573 | Histone acetylation | TAS | biological_process |
| GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter | IC | biological_process |
| GO:0042797 | TRNA transcription from RNA polymerase III promoter | IC | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3961295809 | 0.5574029064 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0738841349 |
| GSE13712_SHEAR | Up | 0.0978894592 |
| GSE13712_STATIC | Up | 0.1061258384 |
| GSE19018 | Down | -0.2812905695 |
| GSE19899_A1 | Up | 0.0795947757 |
| GSE19899_A2 | Up | 0.1207238716 |
| PubMed_21979375_A1 | Up | 0.2947860353 |
| PubMed_21979375_A2 | Up | 0.3026100111 |
| GSE35957 | Down | -0.2210991543 |
| GSE36640 | Down | -0.6052268059 |
| GSE54402 | Up | 0.2465230104 |
| GSE9593 | Up | 0.0546191552 |
| GSE43922 | Up | 0.2100170746 |
| GSE24585 | Down | -0.2355880039 |
| GSE37065 | Down | -0.0734189723 |
| GSE28863_A1 | Up | 0.4127340107 |
| GSE28863_A2 | Up | 0.2349608493 |
| GSE28863_A3 | Down | -0.4769178685 |
| GSE28863_A4 | Down | -0.3130401197 |
| GSE48662 | Up | 0.1418681717 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028677 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031966 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032467 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039620 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043336 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044408 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
