HCSGD entry for DNER
1. General information
| Official gene symbol | DNER |
|---|---|
| Entrez ID | 92737 |
| Gene full name | delta/notch-like EGF repeat containing |
| Other gene symbols | UNQ26 bet |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001764 | Neuron migration | NAS | biological_process |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005112 | Notch binding | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006897 | Endocytosis | NAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007220 | Notch receptor processing | IEA | biological_process |
| GO:0007416 | Synapse assembly | NAS | biological_process |
| GO:0007417 | Central nervous system development | IEP | biological_process |
| GO:0010001 | Glial cell differentiation | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030276 | Clathrin binding | TAS | molecular_function |
| GO:0030425 | Dendrite | IDA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0048741 | Skeletal muscle fiber development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000086547 | 0.9199487405 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.2980398956 |
| GSE13712_SHEAR | Up | 3.4645548705 |
| GSE13712_STATIC | Up | 3.7668946470 |
| GSE19018 | Up | 1.0648969470 |
| GSE19899_A1 | Up | 2.2773943594 |
| GSE19899_A2 | Up | 4.1083626485 |
| PubMed_21979375_A1 | Up | 3.7760407304 |
| PubMed_21979375_A2 | Up | 6.3161415883 |
| GSE35957 | Up | 0.9594581263 |
| GSE36640 | Up | 4.7546638152 |
| GSE54402 | Up | 1.6703538632 |
| GSE9593 | Up | 0.0997776569 |
| GSE43922 | Up | 1.5797641904 |
| GSE24585 | Down | -0.9432210620 |
| GSE37065 | Up | 0.7399995045 |
| GSE28863_A1 | Down | -0.2408842183 |
| GSE28863_A2 | Up | 0.1171037374 |
| GSE28863_A3 | Up | 0.2403683771 |
| GSE28863_A4 | Down | -0.0016977795 |
| GSE48662 | Down | -0.5315414037 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11781307 | Functional inactivation of ERalpha by a dominant negative mutant of ERalpha (DNER) in the presence of activated K-Ras 4B mutant arrested the cell cycle at G(0)/G(1), subsequently provoking replicative cell senescence, finally abrogating tumorigenic potential |
| 11781307 | Alterations in the MDM2 protein in response to DNER accounted for this p21-mediated cell senescence induction |
| 11781307 | In turn, DNER exerted its function to decrease MDM2 proteins coprecipitated with p53, followed by the stimulation of p53 activity in the presence of the oncogenic K-Ras 4B mutant |
| 11781307 | Finally, we demonstrated that c-Jun expression overcame the suppression and resultant enhancement of p21 protein level in response to DNER |
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