HCSGD entry for ITGB1BP1

1. General information

Official gene symbolITGB1BP1
Entrez ID9270
Gene full nameintegrin beta 1 binding protein 1
Other gene symbolsICAP-1A ICAP-1B ICAP-1alpha ICAP1 ICAP1A ICAP1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0002043Blood vessel endothelial cell proliferation involved in sprouting angiogenesisIDAbiological_process
GO:0005092GDP-dissociation inhibitor activityIDAmolecular_function
GO:0005178Integrin bindingIDA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005856CytoskeletonIEA ISScellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0006933Negative regulation of cell adhesion involved in substrate-bound cell migrationIEA ISSbiological_process
GO:0007160Cell-matrix adhesionIDAbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIDA IEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008565Protein transporter activityIDAmolecular_function
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0010764Negative regulation of fibroblast migrationIEA ISSbiological_process
GO:0015031Protein transportIDAbiological_process
GO:0016020MembraneNAScellular_component
GO:0016477Cell migrationTASbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0031214Biomineral tissue developmentIEAbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0033622Integrin activationIEA ISSbiological_process
GO:0033628Regulation of cell adhesion mediated by integrinIEA ISSbiological_process
GO:0035148Tube formationIDAbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIDAbiological_process
GO:0043088Regulation of Cdc42 GTPase activityIDAbiological_process
GO:0043113Receptor clusteringIEA ISSbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIDAbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050880Regulation of blood vessel sizeIDAbiological_process
GO:0051451Myoblast migrationIEA ISSbiological_process
GO:0051496Positive regulation of stress fiber assemblyIEA ISSbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051894Positive regulation of focal adhesion assemblyIEAbiological_process
GO:0051895Negative regulation of focal adhesion assemblyIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0071944Cell peripheryIDAcellular_component
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0090314Positive regulation of protein targeting to membraneIEA ISSbiological_process
GO:0090315Negative regulation of protein targeting to membraneIDAbiological_process
GO:1900025Negative regulation of substrate adhesion-dependent cell spreadingIDAbiological_process
GO:2001044Regulation of integrin-mediated signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75095339080.18237286580.99999024730.8277957751

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1721279545
GSE13712_SHEARUp0.3393001835
GSE13712_STATICUp0.2041636233
GSE19018Up0.0131365264
GSE19899_A1Up0.0120496813
GSE19899_A2Down-0.0664805980
PubMed_21979375_A1Up0.4669241317
PubMed_21979375_A2Up0.0301969337
GSE35957Down-0.1230509685
GSE36640Up0.1000434188
GSE54402Down-0.0037987976
GSE9593Down-0.0331951169
GSE43922Down-0.0408149660
GSE24585Down-0.8535900352
GSE37065Down-0.0640409039
GSE28863_A1Down-0.1069448541
GSE28863_A2Up0.1691693571
GSE28863_A3Down-0.5675674045
GSE28863_A4Down-0.2322010963
GSE48662Down-0.2895210914

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.