HCSGD entry for PDLIM7
1. General information
| Official gene symbol | PDLIM7 |
|---|---|
| Entrez ID | 9260 |
| Gene full name | PDZ and LIM domain 7 (enigma) |
| Other gene symbols | LMP1 LMP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0001725 | Stress fiber | IEA | cellular_component |
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006898 | Receptor-mediated endocytosis | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9620092702 | 0.0144964553 | 0.9999902473 | 0.2367004963 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8932201220 |
| GSE13712_SHEAR | Up | 0.3090568228 |
| GSE13712_STATIC | Up | 0.2130215052 |
| GSE19018 | Down | -0.5502656549 |
| GSE19899_A1 | Down | -0.5929026866 |
| GSE19899_A2 | Down | -0.2954225672 |
| PubMed_21979375_A1 | Up | 0.1250713394 |
| PubMed_21979375_A2 | Down | -0.0896287024 |
| GSE35957 | Down | -0.2819720318 |
| GSE36640 | Down | -0.0199793091 |
| GSE54402 | Down | -0.0376163122 |
| GSE9593 | Down | -0.4002248213 |
| GSE43922 | Down | -0.2575359714 |
| GSE24585 | Up | 0.0654642692 |
| GSE37065 | Down | -0.2412873676 |
| GSE28863_A1 | Down | -0.2677689585 |
| GSE28863_A2 | Down | -0.3453111052 |
| GSE28863_A3 | Down | -0.0505524909 |
| GSE28863_A4 | Down | -0.1278930438 |
| GSE48662 | Down | -0.0843174344 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001351 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001351 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002914 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028432 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030427 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT045848 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26498461 | Epstein-Barr virus (EBV) latent membrane protein-1 (LMP-1) and ligand-independent signaling by overexpressed CD30 are known to cause permanent activation of NF-kappaB in lymphomas |
| 26498461 | Expression of LMP-1 and CD30 increased IkappaB-zeta expression at the transcriptional level |
| 26498461 | Interestingly, IkappaB-zeta inhibited NF-kappaB activation by LMP-1 and CD30 |
| 15064751 | Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells |
| 15064751 | Many of the downstream events of LMP1 expression are mediated through its ability to activate NF-kappaB |
| 15064751 | In this study, we report a novel function of LMP1 to induce Id1 expression in nasopharyngeal epithelial cells (NP69) and human embryonal kidney cells (HEK293) |
| 15064751 | With the combination of both specific chemical inhibitors and genetic inhibitors of cell signaling, we showed that induction of Id1 by LMP1 was dependent on its NF-kappaB activation domain at the carboxy-terminal region, CTAR1 and CTAR2 |
| 15064751 | Induction of Id1 by LMP1 may facilitate clonal expansion of premalignant nasopharyngeal epithelial cells infected with EBV and may promote their malignant transformation |
| 10803461 | LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression |
| 10803461 | Studies indicate that latent membrane protein LMP1 is one of the viral proteins essential for this process |
| 10803461 | In this report, LMP1 was shown to prevent primary mouse embryonic fibroblasts from entering into replicative senescence in vitro |
| 10803461 | In addition, LMP1 was shown to prevent premature senescence provoked by oncogenic ras in mouse embryonic fibroblasts, and to inhibit the oncogene ras-mediated induction of p16INK4a and p21WAF1 |
| 10803461 | In parallel, LMP1 also prevents ras-induced premature senescence in rat embryonic fibroblasts REF52 and human diploid fibroblasts IMR90 |
| 10803461 | Moreover, LMP1 is capable of suppressing the p16INK4a promoter in REF52 and Saos-2 cells in a promoter reporter assay |
| 10803461 | Our findings suggest that with the expression of p16INK4a and replicative senescence being suppressed, LMP1 may play a key role in Epstein-Barr virus-associated proliferative diseases, and it may further contribute to cancer development by preventing premature senescence induced by mitogenic oncogenes |
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