HCSGD entry for NUMBL
1. General information
| Official gene symbol | NUMBL |
|---|---|
| Entrez ID | 9253 |
| Gene full name | numb homolog (Drosophila)-like |
| Other gene symbols | CAG3A CTG3a NBL NUMB-R NUMBLIKE NUMBR TNRC23 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | IDA | biological_process |
| GO:0019538 | Protein metabolic process | IDA | biological_process |
| GO:0021670 | Lateral ventricle development | IEA ISS | biological_process |
| GO:0021849 | Neuroblast division in subventricular zone | IEA ISS | biological_process |
| GO:0034332 | Adherens junction organization | IEA | biological_process |
| GO:0050769 | Positive regulation of neurogenesis | ISS | biological_process |
| GO:0050775 | Positive regulation of dendrite morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8539829832 | 0.1480093120 | 0.9999902473 | 0.7437482054 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1516994424 |
| GSE13712_SHEAR | Up | 0.2619707621 |
| GSE13712_STATIC | Up | 0.1033874559 |
| GSE19018 | Down | -0.1180604609 |
| GSE19899_A1 | Down | -0.2793571493 |
| GSE19899_A2 | Down | -0.0911997521 |
| PubMed_21979375_A1 | Down | -0.9610343647 |
| PubMed_21979375_A2 | Down | -0.7848950256 |
| GSE35957 | Up | 0.1610197276 |
| GSE36640 | Up | 0.1821903507 |
| GSE54402 | Down | -0.1958180917 |
| GSE9593 | Down | -0.1509194671 |
| GSE43922 | Down | -0.0273795134 |
| GSE24585 | Down | -0.0484883253 |
| GSE37065 | Down | -0.2679108706 |
| GSE28863_A1 | Up | 0.5991315928 |
| GSE28863_A2 | Up | 0.2750955057 |
| GSE28863_A3 | Up | 0.0035297372 |
| GSE28863_A4 | Down | -0.0084509552 |
| GSE48662 | Down | -0.0327771957 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003111 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26057707 | Neuroblastoma (NBL) is a heterogeneous tumor characterized by a wide range of clinical manifestations |
| 26057707 | Our hypothesis is that HIF1A and EPAS1 expression represent one of the mechanisms responsible for the lack of responsiveness of NBL to differentiation therapy |
| 26057707 | Clinically, high levels of HIF1A and EPAS1 expression were associated with inferior survival in two NBL microarray datasets, and patient subgroups with lower expression of HIF1A and EPAS1 showed significant enrichment of pathways related to neuronal differentiation |
| 26057707 | These findings open the way for additional lines of attack in the treatment of NBL minimal residue disease |
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