HCSGD entry for MTA2
1. General information
| Official gene symbol | MTA2 |
|---|---|
| Entrez ID | 9219 |
| Gene full name | metastasis associated 1 family, member 2 |
| Other gene symbols | MTA1L1 PID |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000118 | Histone deacetylase complex | TAS | cellular_component |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000989 | Transcription factor binding transcription factor activity | IEA | molecular_function |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | molecular_function |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0004407 | Histone deacetylase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005667 | Transcription factor complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006306 | DNA methylation | IEA | biological_process |
| GO:0006333 | Chromatin assembly or disassembly | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9426450021 | 0.1000331902 | 0.9999902473 | 0.6056990108 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0239848928 |
| GSE13712_SHEAR | Down | -0.0109370230 |
| GSE13712_STATIC | Up | 0.0316410990 |
| GSE19018 | Down | -0.0487081233 |
| GSE19899_A1 | Down | -0.0283103983 |
| GSE19899_A2 | Down | -0.1820228174 |
| PubMed_21979375_A1 | Down | -0.5931492400 |
| PubMed_21979375_A2 | Down | -0.5752225623 |
| GSE35957 | Down | -0.2469809955 |
| GSE36640 | Down | -0.8422311083 |
| GSE54402 | Up | 0.1019517212 |
| GSE9593 | Down | -0.1187554264 |
| GSE43922 | Down | -0.0325969681 |
| GSE24585 | Up | 0.1149271595 |
| GSE37065 | Down | -0.2050012551 |
| GSE28863_A1 | Down | -0.0134965063 |
| GSE28863_A2 | Up | 0.0036180316 |
| GSE28863_A3 | Down | -0.7555004098 |
| GSE28863_A4 | Up | 0.1887675548 |
| GSE48662 | Up | 0.2797131499 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-559 | MIMAT0003223 | MIRT004116 | Western blot | Non-Functional MTI | 19584269 |
| hsa-miR-661 | MIMAT0003324 | MIRT004117 | Western blot | Non-Functional MTI | 19584269 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT004731 | qRT-PCR//Western blot | Functional MTI | 20124483 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017668 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025233 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025233 | Reporter assay;Western blot;Other | Functional MTI | 20018894 |
| hsa-miR-125b-2-3p | MIMAT0004603 | MIRT038634 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040292 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-548a-3p | MIMAT0003251 | MIRT040512 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041029 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042480 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044044 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044965 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046730 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15171255 | PID/MTA2 is a p53-interacting protein that induces p53 deacetylation by recruiting the HDAC1 complex |
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