HCSGD entry for VAPB
1. General information
| Official gene symbol | VAPB |
|---|---|
| Entrez ID | 9217 |
| Gene full name | VAMP (vesicle-associated membrane protein)-associated protein B and C |
| Other gene symbols | ALS8 VAMP-B VAP-B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006874 | Cellular calcium ion homeostasis | IMP | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | IDA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019048 | Modulation by virus of host morphology or physiology | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045070 | Positive regulation of viral genome replication | IMP | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0048487 | Beta-tubulin binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5416314236 | 0.3717304890 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1437206510 |
| GSE13712_SHEAR | Up | 0.1031090009 |
| GSE13712_STATIC | Down | -0.0837449921 |
| GSE19018 | Down | -0.3525733036 |
| GSE19899_A1 | Up | 0.0054841328 |
| GSE19899_A2 | Down | -0.0931540556 |
| PubMed_21979375_A1 | Down | -0.8939373288 |
| PubMed_21979375_A2 | Up | 0.0229437853 |
| GSE35957 | Up | 0.3297020654 |
| GSE36640 | Up | 0.0545833858 |
| GSE54402 | Down | -0.3215501558 |
| GSE9593 | Down | -0.0079182813 |
| GSE43922 | Up | 0.3675539066 |
| GSE24585 | Up | 0.2585685486 |
| GSE37065 | Down | -0.1393456234 |
| GSE28863_A1 | Down | -0.0615260001 |
| GSE28863_A2 | Up | 0.1990259740 |
| GSE28863_A3 | Up | 0.0333128090 |
| GSE28863_A4 | Down | -0.1184077486 |
| GSE48662 | Up | 0.4378864145 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042170 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042809 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043365 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043683 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT050461 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
