HCSGD entry for MTDH
1. General information
| Official gene symbol | MTDH |
|---|---|
| Entrez ID | 92140 |
| Gene full name | metadherin |
| Other gene symbols | 3D3 AEG-1 AEG1 LYRIC LYRIC/3D3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | molecular_function |
| GO:0003713 | Transcription coactivator activity | IMP | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | ISS | cellular_component |
| GO:0005923 | Tight junction | ISS | cellular_component |
| GO:0010508 | Positive regulation of autophagy | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | ISS | cellular_component |
| GO:0016604 | Nuclear body | IDA | cellular_component |
| GO:0031663 | Lipopolysaccharide-mediated signaling pathway | IMP | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IDA | biological_process |
| GO:0046581 | Intercellular canaliculus | ISS | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IDA | biological_process |
| GO:0070830 | Tight junction assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1249620227 | 0.7918351430 | 0.7214576442 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1307491471 |
| GSE13712_SHEAR | Down | -0.1916284185 |
| GSE13712_STATIC | Up | 0.0868328027 |
| GSE19018 | Down | -0.2304278602 |
| GSE19899_A1 | Up | 0.1392991104 |
| GSE19899_A2 | Up | 0.4109252436 |
| PubMed_21979375_A1 | Up | 0.3531779322 |
| PubMed_21979375_A2 | Up | 0.5646027485 |
| GSE35957 | Up | 0.2267969617 |
| GSE36640 | Up | 0.7581222372 |
| GSE54402 | Up | 0.1679019069 |
| GSE9593 | Up | 0.3603591554 |
| GSE43922 | Up | 0.1231767194 |
| GSE24585 | Down | -0.1958314139 |
| GSE37065 | Down | -0.1203588008 |
| GSE28863_A1 | Up | 0.1668188251 |
| GSE28863_A2 | Up | 0.3310260750 |
| GSE28863_A3 | Down | -0.4828609876 |
| GSE28863_A4 | Down | -0.3319967466 |
| GSE48662 | Up | 0.0837690344 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT006207 | Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22508479 |
| hsa-miR-375 | MIMAT0000728 | MIRT006207 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT005920 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20952513 |
| hsa-miR-136-5p | MIMAT0000448 | MIRT006867 | Luciferase reporter assay | Functional MTI | 22967897 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024500 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025258 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026149 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028478 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-139-3p | MIMAT0004552 | MIRT038685 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047972 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24979747 | Further investigation showed that ginsenoside Rg1 protected NSCs/NPCs (neural stem cells/progenitor cells) shown by increased level of SOX-2 expression; reduced astrocytes activation shown by decrease level of Aeg-1 expression; increased the hippocampal cell proliferation; enhanced the activity of the antioxidant enzymes GSH-Px (glutathione peroxidase) and SOD (Superoxide Dismutase); decreased the levels of IL-1beta, IL-6 and TNF-alpha, which are the proinflammatory cytokines; increased the telomere lengths and telomerase activity; and down-regulated the mRNA expression of cellular senescence associated genes p53, p21Cip1/Waf1 and p19Arf in the hippocampus of aged rats |
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