27861555 | ART restored p16 protein expression to levels comparable with HIV-negative subjects in the CD4 compartment, but not in CD8 T cells, which can be an indicative of an irreversible activation/exhaustion status on these cells |
27861555 | Additionally, the frequency of activated CD4+ and CD8+ T cells was positively correlated with p16 expression in CD4+ and CD8+ T cells in untreated subjects |
27824907 | Cytomegalovirus (CMV) infection is common among HIV-infected patients but its repercussion on the course of CD4+ and CD8+ T cells after cART initiation remains elusive |
27824907 | Multivariate analyses using mixed-linear models adjusted for the time from HIV suppression, sex, age, transmission risk group, duration of HIV follow-up, the interaction between time from HIV suppression and CMV+ serology, and the nadir CD4 count revealed a negative correlation between CMV+ and CD4:CD8 ratio (coeff |
27824907 | This correlation was also observed among patients displaying optimal CD4 recovery (>/=500 cells/mm3 at M12; coeff |
27354367 | It is unclear whether differential roles of CD4(+) versus CD8(+) T-cell senescence/exhaustion and effects of antiretroviral therapy (ART) on these processes may contribute to morbidity in treated human immunodeficiency virus type 1 (HIV) infection |
27354367 | Senescent CD4(+) and CD8(+) T cells may have differential roles in HIV pathogenesis |
27073222 | RESULTS: Cases had lower CD4(+) T-cell counts, higher CD8(+) T-cell counts, and increased levels of immune activation (ie, increased soluble CD14 [sCD14] level and increased percentages of CD38(+)HLA-DR(+) cells among both CD4(+) and CD8(+) T cells), regulatory T cells, and percentage of programmed cell death 1 (PD-1)-expressing cells among CD4(+) T cells |
26990630 | CD4 and CD8 cells were analysed for differentiation, senescence, and activation/exhaustion markers by flow cytometry |
26914971 | The CD4(+) memory T cells increased between 3 and 6 mo within the infection group (p = 0 |
26696322 | For senescence-like CD4, but not near-senescent CD8 T cells, these associations remained robust after additional adjustment for CMV status, comorbidities, and inflammation markers |
26696322 | We conclude that CMV seropositivity is linked to a higher incidence of CHD in octogenarians and that senescence in both the CD4 and CD8 T-cell compartments is a predictor of overall cardiovascular mortality as well as death from myocardial infarction and stroke |
26360056 | Unsupervised clustering of the miRNA expression data revealed an age-related clustering in the CD45RO- T cells, while CD45RO+ T cells clustered based on expression of CD4 and CD8 |
26272362 | Immunohistochemistry was used to evaluate the expression of CXCL16/CXCR6, CD3(+) T cells (CD4(+), CD8(+)), and CD20(+) B cells |
26211927 | Cytomegalovirus (CMV) infection profoundly affects the T cell compartment and is associated with alterations in T cell aging parameters and generation of cytotoxic CD4(+) CD28null T cells |
26211927 | They developed CMV-specific CD4(+) and CD8(+) T cells and their T cell compartment shifted towards a more differentiated memory phenotype with expansion of CD4(+) CD28null and CD8(+) CD28null cells |
26146859 | RESULTS: Animals receiving alcohol had increased rates of intestinal T-cell turnover of both CD4+ and CD8+ T cells as reflected by increased BrdU incorporation |
26146859 | CONCLUSIONS: Collectively, these data indicate that alcohol exposure to the small intestine results in marked loss of CD3+ T cells, accompanied by marked increases in CD4+ and CD8+ T-cell proliferation and turnover, which we speculate is an attempt to maintain stable numbers of T cells in tissues |
25733583 | DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia |
25733583 | Idiopathic CD4 lymphopenia (ICL) is a rare heterogeneous immunological syndrome of unclear etiology |
25732234 | Within the CD4(+) population, in the elderly of both sexes there was a significantly higher proportion of late-differentiated TEMRA cells (T effector memory cells re-expressing CD45RA), but these were present exclusively in CMV-positive subjects |
25732234 | Finally, for the first time, we examined the so-called TSCM cell (T-stem cell-like memory) subpopulations in both CD4(+) and CD8(+) subsets and found that neither CMV-seropositivity nor age or sex affected their frequencies |
25688074 | Demographic, clinical and laboratory parameters were collected in all patients and we isolated naive (CD45RA(+)) and memory (CD45RO(+)) CD4(+) and CD8(+) T-cell subsets by MACS technology |
25604328 | METHODS: We carried out a cross-sectional study of 55 patients receiving suppressive combination antiretroviral therapy (cART) for at least 1 year: nine with previous relapsing VL, 20 with an immunodiscordant response (IDR) to cART (CD4 count < 200 cells/muL) and no previous VL, and 26 with a concordant response (CR) to cART (CD4 count > 350 cells/muL) without VL |
25535858 | To better clarify these associations, we investigated the relationships of global sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), and diary-reported sleep duration with telomere length in different immune cell subsets, including granulocytes, peripheral blood mononuclear cells (PBMCs), CD8+ and CD4+ T lymphocytes, and B lymphocytes in a sample of 87 obese men and women (BMI mean=35 |
25089198 | In particular, CD4(+) helper T cells were shown to be essential to the mechanism by which MYC or BCR-ABL inactivation elicits "oncogene withdrawal |
25082296 | Directly post-KTx, memory T-cell numbers were diminished but restored to pre-KTx values at 12 months, except for CD4(+) EM T cells |
25082296 | The RTL of (memory) CD4(+) and CD8(+) T cells did not change |
25082296 | In contrast, TREC content and CD31(+) naive T-cell numbers were stable post-KTx although the RTL of naive CD4(+) and CD8(+) T cells decreased implying homeostatic proliferation of naive cells, in response to a temporary decrease in memory cells |
25001861 | In this observational study, gamma/delta T cell populations were characterized by flow cytometry and compared with the alpha/beta CD4(+) and CD8(+) T cells in elderly and young controls |
25001861 | The extreme range of expression of these markers in gamma/delta T cells was responsible for the lack of relationship between gamma/delta T cell subsets, CD4/CD8 ratio, and anti-CMV titers that was significant for alpha/beta T cells and, especially, CD8(+) T cells |
24185682 | CCR2 or CX3CR1-expressing cells were characterized by double immunofluorescence with CD3, CD4, CD8, CD56 or CD68 |
24185682 | Most CX3CR1-expressing inflammatory cells were CD3-positive T cells (CD8 > CD4) |
24110741 | A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation |
24110741 | Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts |
23962178 | Moreover, increased T cell differentiation was observed with higher percentages of CD57+ and CD28null CD4+ and CD8+ memory T cells |
23940580 | A higher influx of F4/80(+) macrophages and CD4(+) T lymphocytes is measured and is accompanied by increases in mRNA of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) |
23460854 | Among HIV-infected adults, 88% were receiving antiretroviral therapy (ART); their median CD4 count was 468 cells/microL |
23460854 | Among HIV-infected participants, low ECD was independently associated with current CD4 count <200 cells/microL (OR = 2 |
23435301 | DESIGN: We compared markers of immunosenescence, naive T cells, activation, and inflammation in CD4+ and CD8+ T cells from antiretroviral-treated participants with new-onset Kaposi's sarcoma (cases, n = 19) and from treated individuals without Kaposi's sarcoma (controls, n = 47) |
23435301 | RESULTS: There was increased frequency of CD4+ and CD8+ T cells with an immunosenescence phenotype (CD57+ and CD28-) in cases vs |
23435301 | Cases had lower proportions of naive T cells (CD27+ CD28+ CD45RA+) in CD4+ (23 |
23435301 | CCR5 was more highly expressed in CD4+ (16 |
24709644 | The objective of this research was to compare two extracts from Astragalus membranaceus, TA-65 and HTA, for their effects on both telomerase and proliferative activity of human CD4 and CD8 T cells |
22738669 | In patients on cART with suppressed viral loads, however, p16(INK4a) levels were similar to uninfected controls and correlated with chronologic age, with a trend toward an inverse correlation with CD4 count |
22448010 | CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies |
22448010 | Pretreatment and 96-week posttreatment %CD28(-) cells were assessed using linear regression for associations with age, sex, race/ethnicity, CD4 count, HIV RNA, ART regimen, and hepatitis C virus (HCV) infection |
22092365 | RESULTS: Patients with CIN (n = 44) displayed lower proportion of naive CD45RA(+) cells within the CD4(+) and CD8(+) cells compared with controls (n = 15) |
22092365 | The TREC content of CD4(+) and CD8(+) cells was lower in patients compared with controls and was correlated with the proportion of CD45RA(+) CD4(+) and CD8(+) cells and with the levels of serum and BM IL-7, which were significantly decreased in the patients |
22092365 | The mean relative telomere length of CD4(+) and CD8(+) cells was significantly lower in patients with CIN compared with age-matched controls |
21635686 | Recent studies have shown that IL-15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions |
21492857 | METHODS: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers |
20100671 | The frequency of CD57 expression by cervical or blood T cells was not associated with clinical status (CD4 counts) |
19837074 | Interestingly, telomerase activities of CD4+ and CD8+CD28+ T cells from the same individual were strongly correlated (r=0 |
17379755 | Blood lymphocytes isolated before, immediately after, and 1 h after exercise were assessed for cell surface expression of KLRG1, CD57, CD28, CD45RA, CD45RO, CD62L, and lymphocyte subset markers (CD3, CD4, CD8, CD56) by flow cytometry |
17379755 | The change in T-lymphocyte KLRG1 expression was attributed to both CD4+ and CD8 bright T cells, with the relative change being greater for the CD8 bright population (P < 0 |
17321898 | WRN increase was positively correlated to CD4 and CD8 T-cell numbers, and also the percentage of naive T lymphocytes, and was observed also in T-cell subsets |
17202338 | Klotho--a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes |
17202338 | Human CD4(+) T lymphocytes undergo aging-related changes leading to decreased immunity to infections and neoplasms, and to increased frequency of autoimmune diseases including rheumatoid arthritis (RA) |
17202338 | Here we show that KLOTHO, a beta-glucuronidase gene whose activity changes are associated with aging phenotype, is down-regulated at the mRNA, protein, and enzymatic (beta-glucuronidase) activity levels both in the healthy elderly and especially in RA CD4(+) lymphocytes |
16116181 | However, despite this change, there is a lower rate of withdrawal apoptosis in the memory CD4+ and CD8+ T cells |
16116181 | The accumulation of memory T cells with aging explains higher phase II enzyme expression in CD4+ and CD8+ T cells from old mice |
12869504 | Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets |
11985666 | An age-related increase in the CD28- subset was observed in CD8+ T lymphocytes in monkeys less than 11 years old and in CD4+ T lymphocytes in monkeys over 23 years old, respectively |
11985666 | The percentage of CD62L+ subsets was significantly decreased with age in both CD4+ (R = - 0 |
10352273 | CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells |
10102648 | Increased CD4+ T-lymphocyte senescence fraction in advanced human immunodeficiency virus type 1 infection |
10092696 | CONCLUSIONS: Our data indicate substantial activation of both CD4+ and CD8+ lung T cells in sarcoidosis |
9691202 | Upon allostimulation, peripheral blood CD4+ T lymphocytes reproducibly escape from cellular senescence |
9691202 | When cultured continuously, these CD4+ human T lymphocytes gradually lose expression of CD28 |
9615924 | Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens |
7671003 | The proliferative advantage of CD4+ over CD8+ T cells is reversed after the second stimulation |
9435913 | The decline in the percentage of CD28+ T cells correlates with a reduction in the CD4/CD8 ratio (r2 = 0 |
8513512 | In addition, more than 90% of the transfected cells express both the CD4 and "naive" T cell marker, CD45RA |
8513512 | In order to investigate whether the lack of long-lived CD8+ cells reflects phenotypic restriction, separated CD4+ and CD8+ subpopulations were transfected with SV40 large T |
8513512 | All transfections resulted in extended life spans of CD4+, but not CD8+, cells |
15374448 | The declines in vitro responses cannot be explained by decrease in numbers of differentiated T cells or by age-associated changes in the proportion of CD4+ 'helper' to CD8+ 'cytotoxic/suppressor' T cells |