HCSGD entry for CD4


1. General information

Official gene symbolCD4
Entrez ID920
Gene full nameCD4 molecule
Other gene symbolsCD4mut
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionIEAbiological_process
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityTASmolecular_function
GO:0005201Extracellular matrix structural constituentNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005769Early endosomeTAScellular_component
GO:0005788Endoplasmic reticulum lumenIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEA TAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006948Induction by virus of host cell-cell fusionIDAbiological_process
GO:0006955Immune responseNASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEA TASbiological_process
GO:0007167Enzyme linked receptor protein signaling pathwayTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayNASbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009897External side of plasma membraneIDA IEAcellular_component
GO:0015026Coreceptor activityNASmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIEA IPImolecular_function
GO:0030217T cell differentiationIDAbiological_process
GO:0030260Entry into host cellTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0032507Maintenance of protein location in cellIDAbiological_process
GO:0042101T cell receptor complexNAScellular_component
GO:0042110T cell activationIEAbiological_process
GO:0042289MHC class II protein bindingNASmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0045058T cell selectionIDAbiological_process
GO:0045086Positive regulation of interleukin-2 biosynthetic processNASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045234Protein palmitoleylationIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050829Defense response to Gram-negative bacteriumIEAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050863Regulation of T cell activationIDAbiological_process
GO:0050870Positive regulation of T cell activationIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85101277310.12403393870.99999024730.6771825970

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0629505443
GSE13712_SHEARDown-0.2334631070
GSE13712_STATICDown-0.0678006548
GSE19018Up0.0320254291
GSE19899_A1Down-0.0330969607
GSE19899_A2Down-0.0002799404
PubMed_21979375_A1Down-0.4640532709
PubMed_21979375_A2Down-0.0426779946
GSE35957Up0.0050658963
GSE36640Up0.4905900224
GSE54402Down-0.2386492550
GSE9593Down-0.2621871564
GSE43922Down-1.0585638129
GSE24585Up0.1218109772
GSE37065Down-0.1728002155
GSE28863_A1Down-0.1479346006
GSE28863_A2Down-0.4523741535
GSE28863_A3Up0.2134975758
GSE28863_A4Up0.1392317919
GSE48662Up0.5401287544

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Anti-thymocyte Globulin (Rabbit)DB00098 BTD00040 | BIOD00040

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 48 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27861555ART restored p16 protein expression to levels comparable with HIV-negative subjects in the CD4 compartment, but not in CD8 T cells, which can be an indicative of an irreversible activation/exhaustion status on these cells
27861555Additionally, the frequency of activated CD4+ and CD8+ T cells was positively correlated with p16 expression in CD4+ and CD8+ T cells in untreated subjects
27824907Cytomegalovirus (CMV) infection is common among HIV-infected patients but its repercussion on the course of CD4+ and CD8+ T cells after cART initiation remains elusive
27824907Multivariate analyses using mixed-linear models adjusted for the time from HIV suppression, sex, age, transmission risk group, duration of HIV follow-up, the interaction between time from HIV suppression and CMV+ serology, and the nadir CD4 count revealed a negative correlation between CMV+ and CD4:CD8 ratio (coeff
27824907This correlation was also observed among patients displaying optimal CD4 recovery (>/=500 cells/mm3 at M12; coeff
27354367It is unclear whether differential roles of CD4(+) versus CD8(+) T-cell senescence/exhaustion and effects of antiretroviral therapy (ART) on these processes may contribute to morbidity in treated human immunodeficiency virus type 1 (HIV) infection
27354367Senescent CD4(+) and CD8(+) T cells may have differential roles in HIV pathogenesis
27073222RESULTS: Cases had lower CD4(+) T-cell counts, higher CD8(+) T-cell counts, and increased levels of immune activation (ie, increased soluble CD14 [sCD14] level and increased percentages of CD38(+)HLA-DR(+) cells among both CD4(+) and CD8(+) T cells), regulatory T cells, and percentage of programmed cell death 1 (PD-1)-expressing cells among CD4(+) T cells
26990630CD4 and CD8 cells were analysed for differentiation, senescence, and activation/exhaustion markers by flow cytometry
26914971The CD4(+) memory T cells increased between 3 and 6 mo within the infection group (p = 0
26696322For senescence-like CD4, but not near-senescent CD8 T cells, these associations remained robust after additional adjustment for CMV status, comorbidities, and inflammation markers
26696322We conclude that CMV seropositivity is linked to a higher incidence of CHD in octogenarians and that senescence in both the CD4 and CD8 T-cell compartments is a predictor of overall cardiovascular mortality as well as death from myocardial infarction and stroke
26360056Unsupervised clustering of the miRNA expression data revealed an age-related clustering in the CD45RO- T cells, while CD45RO+ T cells clustered based on expression of CD4 and CD8
26272362Immunohistochemistry was used to evaluate the expression of CXCL16/CXCR6, CD3(+) T cells (CD4(+), CD8(+)), and CD20(+) B cells
26211927Cytomegalovirus (CMV) infection profoundly affects the T cell compartment and is associated with alterations in T cell aging parameters and generation of cytotoxic CD4(+) CD28null T cells
26211927They developed CMV-specific CD4(+) and CD8(+) T cells and their T cell compartment shifted towards a more differentiated memory phenotype with expansion of CD4(+) CD28null and CD8(+) CD28null cells
26146859RESULTS: Animals receiving alcohol had increased rates of intestinal T-cell turnover of both CD4+ and CD8+ T cells as reflected by increased BrdU incorporation
26146859CONCLUSIONS: Collectively, these data indicate that alcohol exposure to the small intestine results in marked loss of CD3+ T cells, accompanied by marked increases in CD4+ and CD8+ T-cell proliferation and turnover, which we speculate is an attempt to maintain stable numbers of T cells in tissues
25733583DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia
25733583Idiopathic CD4 lymphopenia (ICL) is a rare heterogeneous immunological syndrome of unclear etiology
25732234Within the CD4(+) population, in the elderly of both sexes there was a significantly higher proportion of late-differentiated TEMRA cells (T effector memory cells re-expressing CD45RA), but these were present exclusively in CMV-positive subjects
25732234Finally, for the first time, we examined the so-called TSCM cell (T-stem cell-like memory) subpopulations in both CD4(+) and CD8(+) subsets and found that neither CMV-seropositivity nor age or sex affected their frequencies
25688074Demographic, clinical and laboratory parameters were collected in all patients and we isolated naive (CD45RA(+)) and memory (CD45RO(+)) CD4(+) and CD8(+) T-cell subsets by MACS technology
25604328METHODS: We carried out a cross-sectional study of 55 patients receiving suppressive combination antiretroviral therapy (cART) for at least 1 year: nine with previous relapsing VL, 20 with an immunodiscordant response (IDR) to cART (CD4 count < 200 cells/muL) and no previous VL, and 26 with a concordant response (CR) to cART (CD4 count > 350 cells/muL) without VL
25535858To better clarify these associations, we investigated the relationships of global sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), and diary-reported sleep duration with telomere length in different immune cell subsets, including granulocytes, peripheral blood mononuclear cells (PBMCs), CD8+ and CD4+ T lymphocytes, and B lymphocytes in a sample of 87 obese men and women (BMI mean=35
25089198In particular, CD4(+) helper T cells were shown to be essential to the mechanism by which MYC or BCR-ABL inactivation elicits "oncogene withdrawal
25082296Directly post-KTx, memory T-cell numbers were diminished but restored to pre-KTx values at 12 months, except for CD4(+) EM T cells
25082296The RTL of (memory) CD4(+) and CD8(+) T cells did not change
25082296In contrast, TREC content and CD31(+) naive T-cell numbers were stable post-KTx although the RTL of naive CD4(+) and CD8(+) T cells decreased implying homeostatic proliferation of naive cells, in response to a temporary decrease in memory cells
25001861In this observational study, gamma/delta T cell populations were characterized by flow cytometry and compared with the alpha/beta CD4(+) and CD8(+) T cells in elderly and young controls
25001861The extreme range of expression of these markers in gamma/delta T cells was responsible for the lack of relationship between gamma/delta T cell subsets, CD4/CD8 ratio, and anti-CMV titers that was significant for alpha/beta T cells and, especially, CD8(+) T cells
24185682CCR2 or CX3CR1-expressing cells were characterized by double immunofluorescence with CD3, CD4, CD8, CD56 or CD68
24185682Most CX3CR1-expressing inflammatory cells were CD3-positive T cells (CD8 > CD4)
24110741A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation
24110741Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts
23962178Moreover, increased T cell differentiation was observed with higher percentages of CD57+ and CD28null CD4+ and CD8+ memory T cells
23940580A higher influx of F4/80(+) macrophages and CD4(+) T lymphocytes is measured and is accompanied by increases in mRNA of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha)
23460854Among HIV-infected adults, 88% were receiving antiretroviral therapy (ART); their median CD4 count was 468 cells/microL
23460854Among HIV-infected participants, low ECD was independently associated with current CD4 count <200 cells/microL (OR = 2
23435301DESIGN: We compared markers of immunosenescence, naive T cells, activation, and inflammation in CD4+ and CD8+ T cells from antiretroviral-treated participants with new-onset Kaposi's sarcoma (cases, n = 19) and from treated individuals without Kaposi's sarcoma (controls, n = 47)
23435301RESULTS: There was increased frequency of CD4+ and CD8+ T cells with an immunosenescence phenotype (CD57+ and CD28-) in cases vs
23435301Cases had lower proportions of naive T cells (CD27+ CD28+ CD45RA+) in CD4+ (23
23435301CCR5 was more highly expressed in CD4+ (16
24709644The objective of this research was to compare two extracts from Astragalus membranaceus, TA-65 and HTA, for their effects on both telomerase and proliferative activity of human CD4 and CD8 T cells
22738669In patients on cART with suppressed viral loads, however, p16(INK4a) levels were similar to uninfected controls and correlated with chronologic age, with a trend toward an inverse correlation with CD4 count
22448010CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies
22448010Pretreatment and 96-week posttreatment %CD28(-) cells were assessed using linear regression for associations with age, sex, race/ethnicity, CD4 count, HIV RNA, ART regimen, and hepatitis C virus (HCV) infection
22092365RESULTS: Patients with CIN (n = 44) displayed lower proportion of naive CD45RA(+) cells within the CD4(+) and CD8(+) cells compared with controls (n = 15)
22092365The TREC content of CD4(+) and CD8(+) cells was lower in patients compared with controls and was correlated with the proportion of CD45RA(+) CD4(+) and CD8(+) cells and with the levels of serum and BM IL-7, which were significantly decreased in the patients
22092365The mean relative telomere length of CD4(+) and CD8(+) cells was significantly lower in patients with CIN compared with age-matched controls
21635686Recent studies have shown that IL-15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions
21492857METHODS: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers
20100671The frequency of CD57 expression by cervical or blood T cells was not associated with clinical status (CD4 counts)
19837074Interestingly, telomerase activities of CD4+ and CD8+CD28+ T cells from the same individual were strongly correlated (r=0
17379755Blood lymphocytes isolated before, immediately after, and 1 h after exercise were assessed for cell surface expression of KLRG1, CD57, CD28, CD45RA, CD45RO, CD62L, and lymphocyte subset markers (CD3, CD4, CD8, CD56) by flow cytometry
17379755The change in T-lymphocyte KLRG1 expression was attributed to both CD4+ and CD8 bright T cells, with the relative change being greater for the CD8 bright population (P < 0
17321898WRN increase was positively correlated to CD4 and CD8 T-cell numbers, and also the percentage of naive T lymphocytes, and was observed also in T-cell subsets
17202338Klotho--a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes
17202338Human CD4(+) T lymphocytes undergo aging-related changes leading to decreased immunity to infections and neoplasms, and to increased frequency of autoimmune diseases including rheumatoid arthritis (RA)
17202338Here we show that KLOTHO, a beta-glucuronidase gene whose activity changes are associated with aging phenotype, is down-regulated at the mRNA, protein, and enzymatic (beta-glucuronidase) activity levels both in the healthy elderly and especially in RA CD4(+) lymphocytes
16116181However, despite this change, there is a lower rate of withdrawal apoptosis in the memory CD4+ and CD8+ T cells
16116181The accumulation of memory T cells with aging explains higher phase II enzyme expression in CD4+ and CD8+ T cells from old mice
12869504Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets
11985666An age-related increase in the CD28- subset was observed in CD8+ T lymphocytes in monkeys less than 11 years old and in CD4+ T lymphocytes in monkeys over 23 years old, respectively
11985666The percentage of CD62L+ subsets was significantly decreased with age in both CD4+ (R = - 0
10352273CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells
10102648Increased CD4+ T-lymphocyte senescence fraction in advanced human immunodeficiency virus type 1 infection
10092696CONCLUSIONS: Our data indicate substantial activation of both CD4+ and CD8+ lung T cells in sarcoidosis
9691202Upon allostimulation, peripheral blood CD4+ T lymphocytes reproducibly escape from cellular senescence
9691202When cultured continuously, these CD4+ human T lymphocytes gradually lose expression of CD28
9615924Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens
7671003The proliferative advantage of CD4+ over CD8+ T cells is reversed after the second stimulation
9435913The decline in the percentage of CD28+ T cells correlates with a reduction in the CD4/CD8 ratio (r2 = 0
8513512In addition, more than 90% of the transfected cells express both the CD4 and "naive" T cell marker, CD45RA
8513512In order to investigate whether the lack of long-lived CD8+ cells reflects phenotypic restriction, separated CD4+ and CD8+ subpopulations were transfected with SV40 large T
8513512All transfections resulted in extended life spans of CD4+, but not CD8+, cells
15374448The declines in vitro responses cannot be explained by decrease in numbers of differentiated T cells or by age-associated changes in the proportion of CD4+ 'helper' to CD8+ 'cytotoxic/suppressor' T cells
Entries Per Page
Displaying Page of