HCSGD entry for BUB3
1. General information
| Official gene symbol | BUB3 |
|---|---|
| Entrez ID | 9184 |
| Gene full name | BUB3 mitotic checkpoint protein |
| Other gene symbols | BUB3L hBUB3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000070 | Mitotic sister chromatid segregation | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007094 | Mitotic spindle assembly checkpoint | TAS | biological_process |
| GO:0007126 | Meiosis | IEA | biological_process |
| GO:0008608 | Attachment of spindle microtubules to kinetochore | IDA | biological_process |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051983 | Regulation of chromosome segregation | IEA | biological_process |
| GO:0071173 | Spindle assembly checkpoint | IDA IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8289346491 | 0.2091222294 | 0.9999902473 | 0.8845100755 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1620700016 |
| GSE13712_SHEAR | Up | 0.1041393741 |
| GSE13712_STATIC | Up | 0.1011766200 |
| GSE19018 | Up | 0.0371875989 |
| GSE19899_A1 | Down | -0.0253429230 |
| GSE19899_A2 | Down | -0.2788473814 |
| PubMed_21979375_A1 | Up | 0.0045705093 |
| PubMed_21979375_A2 | Down | -0.2441795903 |
| GSE35957 | Down | -0.3993742566 |
| GSE36640 | Down | -1.1637109520 |
| GSE54402 | Down | -0.0134886559 |
| GSE9593 | Down | -0.1337404235 |
| GSE43922 | Up | 0.0251711005 |
| GSE24585 | Down | -0.0071989089 |
| GSE37065 | Down | -0.0111573222 |
| GSE28863_A1 | Up | 0.3042677744 |
| GSE28863_A2 | Up | 0.3886140261 |
| GSE28863_A3 | Down | -0.2876966284 |
| GSE28863_A4 | Down | -0.0638045197 |
| GSE48662 | Down | -0.3837176412 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7d-5p | MIMAT0000065 | MIRT032111 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-3p | MIMAT0004946 | MIRT037378 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039843 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16600919 | Interestingly, a recent study has shed light on a new function of the spindle checkpoint components Bub3 and Rae1 in the regulation of aging |
| 16600919 | Mice with haploinsufficiency of Bub3 and Rae1 have a short life span that is associated with the early onset of aging-related features |
| 16600919 | The progeroid phenotypes caused by deficiency of Bub3 and Rae1 are tightly linked to precocious activation of cellular senescence, but not apoptotic, programs |
| 16476774 | Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice |
| 16476774 | In this study, we show that several aging-associated phenotypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice that are single haploinsufficient for these genes |
| 16476774 | Furthermore, although BubR1 hypomorphic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster |
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