HCSGD entry for ARHGEF2

1. General information

Official gene symbolARHGEF2
Entrez ID9181
Gene full nameRho/Rac guanine nucleotide exchange factor (GEF) 2
Other gene symbolsGEF GEF-H1 GEFH1 LFP40 P40
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000132Establishment of mitotic spindle orientationIEAbiological_process
GO:0000902Cell morphogenesisIMPbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIDAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005923Tight junctionIEAcellular_component
GO:0006886Intracellular protein transportNASbiological_process
GO:0007015Actin filament organizationIMPbiological_process
GO:0007026Negative regulation of microtubule depolymerizationIMPbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008134Transcription factor bindingISSmolecular_function
GO:0008270Zinc ion bindingNASmolecular_function
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0017048Rho GTPase bindingIDAmolecular_function
GO:0030676Rac guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0031982VesicleIDAcellular_component
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0032318Regulation of Ras GTPase activityIDAbiological_process
GO:0032319Regulation of Rho GTPase activityIDAbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDAbiological_process
GO:0035023Regulation of Rho protein signal transductionNASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042127Regulation of cell proliferationTASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0043198Dendritic shaftIEAcellular_component
GO:0043234Protein complexIDAcellular_component
GO:0045087Innate immune responseIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048365Rac GTPase bindingIDAmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050768Negative regulation of neurogenesisIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0060547Negative regulation of necrotic cell deathISSbiological_process
GO:0071225Cellular response to muramyl dipeptideIDAbiological_process
GO:0071356Cellular response to tumor necrosis factorISSbiological_process
GO:0071474Cellular hyperosmotic responseISSbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsISSbiological_process
GO:1902219Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39204257820.44292356670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0541679267
GSE13712_SHEARUp0.1101214339
GSE13712_STATICDown-0.1456731020
GSE19018Up0.0105215161
GSE19899_A1Up0.1235496998
GSE19899_A2Up0.1652992767
PubMed_21979375_A1Down-0.2488336655
PubMed_21979375_A2Down-0.0707676281
GSE35957Down-0.2183668866
GSE36640Down-0.1251883972
GSE54402Down-0.3099207435
GSE9593Up0.3040999668
GSE43922Up0.4638988891
GSE24585Up0.0940707108
GSE37065Down-0.3188508268
GSE28863_A1Down-0.0210479321
GSE28863_A2Down-0.0702957074
GSE28863_A3Up0.2908576723
GSE28863_A4Down-0.2033999435
GSE48662Up0.4990443620

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018030MicroarrayFunctional MTI (Weak)18185580
hsa-miR-96-5pMIMAT0000095MIRT027914SequencingFunctional MTI (Weak)20371350
hsa-miR-877-3pMIMAT0004950MIRT037159CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037439CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042542CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044440CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.