HCSGD entry for NLRP12

1. General information

Official gene symbolNLRP12
Entrez ID91662
Gene full nameNLR family, pyrin domain containing 12
Other gene symbolsCLR19.3 FCAS2 NALP12 PAN6 PYPAF7 RNO RNO2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processNASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008588Release of cytoplasmic sequestered NF-kappaBIDAbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processNASmolecular_function
GO:0009968Negative regulation of signal transductionIDAbiological_process
GO:0031953Negative regulation of protein autophosphorylationIDAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0036336Dendritic cell migrationIEAbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0045381Regulation of interleukin-18 biosynthetic processNASbiological_process
GO:0045409Negative regulation of interleukin-6 biosynthetic processIDAbiological_process
GO:0045751Negative regulation of Toll signaling pathwayIDAbiological_process
GO:0050710Negative regulation of cytokine secretionIDAbiological_process
GO:0050711Negative regulation of interleukin-1 secretionIDAbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionNASbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0050729Positive regulation of inflammatory responseNASbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071345Cellular response to cytokine stimulusIEAbiological_process
GO:1901223Negative regulation of NIK/NF-kappaB signalingIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82966144140.73935986090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1367820688
GSE13712_SHEARDown-0.0204043195
GSE13712_STATICUp0.0040046491
GSE19018Down-0.0279986965
GSE19899_A1Up0.0918630586
GSE19899_A2Up0.2560069498
PubMed_21979375_A1Down-0.2408245692
PubMed_21979375_A2Down-0.0740928700
GSE35957Up0.0563461125
GSE36640Down-0.0569115735
GSE54402Up0.0087193205
GSE9593Down-0.1350193597
GSE43922Up0.0242337970
GSE24585Up0.1355400967
GSE37065Down-0.0056902090
GSE28863_A1Down-0.0999465818
GSE28863_A2Up0.0094016792
GSE28863_A3Up0.1236826575
GSE28863_A4Up0.1290295517
GSE48662Down-0.0275019367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17339088Telomerase, a reverse transcriptase involved in the maintenance of telomere function and cellular replicative capacity, is thought to be regulated by nitric oxide (NO)
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