HCSGD entry for CD3E

1. General information

Official gene symbolCD3E
Entrez ID916
Gene full nameCD3e molecule, epsilon (CD3-TCR complex)
Other gene symbolsT3E TCRE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001772Immunological synapseIEAcellular_component
GO:0002669Positive regulation of T cell anergyIEAbiological_process
GO:0004888Transmembrane signaling receptor activityIEA NASmolecular_function
GO:0005057Receptor signaling protein activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006461Protein complex assemblyNASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEA NASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007172Signal complex assemblyTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0017124SH3 domain bindingIPImolecular_function
GO:0019901Protein kinase bindingNASmolecular_function
GO:0030159Receptor signaling complex scaffold activityNASmolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIEAbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042101T cell receptor complexIDA NAScellular_component
GO:0042102Positive regulation of T cell proliferationIMPbiological_process
GO:0042105Alpha-beta T cell receptor complexIEAcellular_component
GO:0042110T cell activationNASbiological_process
GO:0042608T cell receptor bindingNASmolecular_function
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045086Positive regulation of interleukin-2 biosynthetic processIEAbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayIEAbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0097190Apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64681081270.58906956040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2572394230
GSE13712_SHEARDown-0.1118411244
GSE13712_STATICUp0.0179584629
GSE19018Up0.1975923874
GSE19899_A1Up0.2532853737
GSE19899_A2Down-0.2131128387
PubMed_21979375_A1Down-0.1202894833
PubMed_21979375_A2Up0.0279703032
GSE35957Up0.1775630591
GSE36640Up0.1252116376
GSE54402Down-0.0545924634
GSE9593Up0.1411846749
GSE43922Up0.0752078430
GSE24585Down-0.0605483689
GSE37065Down-0.1403877319
GSE28863_A1Down-0.1015035981
GSE28863_A2Up0.0976034634
GSE28863_A3Up0.2354654211
GSE28863_A4Down-0.0142778799
GSE48662Down-0.0891913730

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MuromonabDB00075 BTD00005 | BIOD00005

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.