HCSGD entry for PCSK7
1. General information
| Official gene symbol | PCSK7 |
|---|---|
| Entrez ID | 9159 |
| Gene full name | proprotein convertase subtilisin/kexin type 7 |
| Other gene symbols | LPC PC7 PC8 SPC7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IBA IEA | molecular_function |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0016486 | Peptide hormone processing | NAS | biological_process |
| GO:0030173 | Integral component of Golgi membrane | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8468752707 | 0.0159200828 | 0.9999902473 | 0.2461419355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1327571806 |
| GSE13712_SHEAR | Up | 0.5066095875 |
| GSE13712_STATIC | Up | 0.3010753648 |
| GSE19018 | Down | -0.6432394235 |
| GSE19899_A1 | Down | -0.2685260371 |
| GSE19899_A2 | Down | -0.3515984257 |
| PubMed_21979375_A1 | Down | -0.8502472224 |
| PubMed_21979375_A2 | Up | 0.4642123463 |
| GSE35957 | Down | -0.2710762287 |
| GSE36640 | Up | 0.7952505592 |
| GSE54402 | Up | 0.1278568782 |
| GSE9593 | Down | -0.3325107835 |
| GSE43922 | Down | -0.2725107305 |
| GSE24585 | Up | 0.0574708799 |
| GSE37065 | Down | -0.3458455117 |
| GSE28863_A1 | Down | -0.7112731307 |
| GSE28863_A2 | Down | -1.2762701426 |
| GSE28863_A3 | Down | -0.2327993691 |
| GSE28863_A4 | Down | -0.0908251345 |
| GSE48662 | Down | -0.1871903443 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-652-3p | MIMAT0003322 | MIRT039521 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25921542 | In these diseases, biliary lysophosphatidylcholine (LPC) level is reportedly increased |
| 25921542 | This study investigated the influence of LPC on cholangiocytes focusing on cellular senescence and its potential contribution to carcinogenesis |
| 25921542 | METHODS: Cultured MMNK-1, an immortalized human cholangiocyte was treated with LPC in vitro and its effect was evaluated |
| 25921542 | Accordingly, LPC provoked oxidative DNA injury, whereas the gene expressions of DNA repair enzyme (OGG1, MUTYH, MTH1) remained unchanged |
| 25921542 | Interestingly, LPC caused global DNA hypomethylation, which is frequently observed in cancer tissues |
| 25921542 | Microarray analysis identified differentially regulated genes in response to LPC, which included the components of senescence-associated secretory phenotype (SASP) including interleukin-8 (IL-8), IL-6, transforming growth factor-beta and plasminogen activator inhibitor-1 |
| 25921542 | In addition to upregulation of p21 gene expression, senescence-associated beta-galactosidase activity, a widely used marker of cellular senescence was significantly induced by the treatment of LPC |
| 25921542 | CONCLUSIONS: Based on these data, cholangiocyte senescence and SASP caused by LPC are potential pathogenic mechanisms in the development of biliary tract cancer |
| 24498988 | We used structural analysis with representative standards and spectrum patterns with different collision energies to distinctly identify eight metabolites with altered expression during senescence as types of lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), such as LPC 16:0 and LPE 22:4 |
Entries Per Page
Displaying Page of
