HCSGD entry for EXO1
1. General information
| Official gene symbol | EXO1 |
|---|---|
| Entrez ID | 9156 |
| Gene full name | exonuclease 1 |
| Other gene symbols | HEX1 hExoI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000737 | DNA catabolic process, endonucleolytic | IDA | biological_process |
| GO:0000738 | DNA catabolic process, exonucleolytic | IDA | biological_process |
| GO:0002455 | Humoral immune response mediated by circulating immunoglobulin | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0004518 | Nuclease activity | IEA | molecular_function |
| GO:0004523 | RNA-DNA hybrid ribonuclease activity | TAS | molecular_function |
| GO:0004527 | Exonuclease activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006298 | Mismatch repair | IDA IMP IPI ISS | biological_process |
| GO:0006308 | DNA catabolic process | IDA | biological_process |
| GO:0006310 | DNA recombination | IGI | biological_process |
| GO:0007126 | Meiosis | IEA | biological_process |
| GO:0008409 | 5'-3' exonuclease activity | ISS | molecular_function |
| GO:0016446 | Somatic hypermutation of immunoglobulin genes | IEA | biological_process |
| GO:0035312 | 5'-3' exodeoxyribonuclease activity | IDA | molecular_function |
| GO:0043566 | Structure-specific DNA binding | IEA | molecular_function |
| GO:0045145 | Single-stranded DNA 5'-3' exodeoxyribonuclease activity | IDA | molecular_function |
| GO:0045190 | Isotype switching | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048256 | Flap endonuclease activity | IDA | molecular_function |
| GO:0051908 | Double-stranded DNA 5'-3' exodeoxyribonuclease activity | IDA | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA ISS TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | TAS | biological_process |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9788774781 | 0.0001815243 | 0.9999902473 | 0.0245860000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3154928411 |
| GSE13712_SHEAR | Up | 0.0421967564 |
| GSE13712_STATIC | Up | 0.1006918601 |
| GSE19018 | Down | -0.1885516460 |
| GSE19899_A1 | Down | -0.3337770275 |
| GSE19899_A2 | Down | -3.6050306984 |
| PubMed_21979375_A1 | Down | -1.4999854984 |
| PubMed_21979375_A2 | Down | -2.0536228132 |
| GSE35957 | Down | -1.7045157397 |
| GSE36640 | Down | -4.1217697765 |
| GSE54402 | Down | -0.4262771094 |
| GSE9593 | Down | -0.9273200116 |
| GSE43922 | Down | -1.3789921484 |
| GSE24585 | Down | -0.0268855993 |
| GSE37065 | Down | -0.4847562134 |
| GSE28863_A1 | Down | -0.3406994407 |
| GSE28863_A2 | Up | 1.0584003347 |
| GSE28863_A3 | Down | -0.5574153220 |
| GSE28863_A4 | Down | -0.0778422224 |
| GSE48662 | Down | -1.7731809852 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016312 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-375 | MIMAT0000728 | MIRT019671 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044161 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19380905 | In the Saccharomyces cerevisiae strain W303, telomerase-null populations bypass senescence and, unless EXO1 is also deleted, this survival is RAD52 dependent |
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