HCSGD entry for HGS

1. General information

Official gene symbolHGS
Entrez ID9146
Gene full namehepatocyte growth factor-regulated tyrosine kinase substrate
Other gene symbolsHRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006886Intracellular protein transportIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0008333Endosome to lysosome transportIEAbiological_process
GO:0009966Regulation of signal transductionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016197Endosomal transportIEA NAS TASbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030141Secretory granuleIEAcellular_component
GO:0031901Early endosome membraneIEAcellular_component
GO:0032585Multivesicular body membraneIEAcellular_component
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0042176Regulation of protein catabolic processTASbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0046426Negative regulation of JAK-STAT cascadeIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09277868240.96730925880.63901174161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0995900857
GSE13712_SHEARUp0.3726187835
GSE13712_STATICUp0.5630867480
GSE19018Up0.1539231301
GSE19899_A1Down-0.1554318678
GSE19899_A2Up0.1300091933
PubMed_21979375_A1Up0.5274485973
PubMed_21979375_A2Up0.9334372559
GSE35957Down-0.3709628620
GSE36640Down-0.0057924006
GSE54402Up0.2187818406
GSE9593Up0.0695539396
GSE43922Up0.0241707596
GSE24585Up0.1382067965
GSE37065Down-0.0333486039
GSE28863_A1Up0.1091413650
GSE28863_A2Up0.3173828920
GSE28863_A3Up0.2914179953
GSE28863_A4Up0.0514192032
GSE48662Up0.0158103984

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Citric AcidDB04272 EXPT00922

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-5pMIMAT0000690MIRT004900Luciferase reporter assay//Western blotFunctional MTI18977327
hsa-miR-877-3pMIMAT0004950MIRT037009CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042598CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052221CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-296-5pMIMAT00006901hsa-miR-296-5p18977327
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.