HCSGD entry for SMC3


1. General information

Official gene symbolSMC3
Entrez ID9126
Gene full namestructural maintenance of chromosomes 3
Other gene symbolsBAM BMH CDLS3 CSPG6 HCAP SMC3L1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionTAScellular_component
GO:0000785ChromatinIDAcellular_component
GO:0000800Lateral elementIEAcellular_component
GO:0000922Spindle poleIDAcellular_component
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003777Microtubule motor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005604Basement membraneTAScellular_component
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005694ChromosomeTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006275Regulation of DNA replicationIMPbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0007052Mitotic spindle organizationIEPbiological_process
GO:0007062Sister chromatid cohesionIMP NASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007126MeiosisIDAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008278Cohesin complexNAScellular_component
GO:0016363Nuclear matrixIDAcellular_component
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0030893Meiotic cohesin complexIDAcellular_component
GO:0032876Negative regulation of DNA endoreduplicationIMPbiological_process
GO:0034991Nuclear meiotic cohesin complexIEAcellular_component
GO:0036033Mediator complex bindingIEAmolecular_function
GO:0045502Dynein bindingIDAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70630238210.01641039470.99999024730.2498195489

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1533729713
GSE13712_SHEARUp0.0910387197
GSE13712_STATICDown-0.2595730475
GSE19018Up0.1743938652
GSE19899_A1Down-0.2403005028
GSE19899_A2Down-1.0506449822
PubMed_21979375_A1Down-0.9541228021
PubMed_21979375_A2Down-1.1315511410
GSE35957Down-0.5063930927
GSE36640Down-1.1451815570
GSE54402Down-0.1493145673
GSE9593Down-0.2032209359
GSE43922Down-0.8104252423
GSE24585Down-0.1272984575
GSE37065Up0.0822152587
GSE28863_A1Up0.4078204766
GSE28863_A2Up0.6358298689
GSE28863_A3Up0.3071555553
GSE28863_A4Up0.2722447131
GSE48662Down-0.7385159980

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-340-5pMIMAT0004692MIRT019626SequencingFunctional MTI (Weak)20371350
hsa-miR-196a-5pMIMAT0000226MIRT026077SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040180CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041357CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049364CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.