HCSGD entry for LATS1
1. General information
| Official gene symbol | LATS1 |
|---|---|
| Entrez ID | 9113 |
| Gene full name | large tumor suppressor kinase 1 |
| Other gene symbols | WARTS wts |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IDA | biological_process |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0000819 | Sister chromatid segregation | IDA | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0004674 | Protein serine/threonine kinase activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0009755 | Hormone-mediated signaling pathway | ISS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0030833 | Regulation of actin filament polymerization | IDA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0035329 | Hippo signaling | IDA TAS | biological_process |
| GO:0043254 | Regulation of protein complex assembly | IMP | biological_process |
| GO:0045736 | Negative regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | biological_process |
| GO:0051220 | Cytoplasmic sequestering of protein | IMP | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2207527222 | 0.5215952053 | 0.9019175229 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1106866343 |
| GSE13712_SHEAR | Up | 0.1939956134 |
| GSE13712_STATIC | Up | 0.2560311058 |
| GSE19018 | Down | -0.0257266917 |
| GSE19899_A1 | Up | 0.2430828377 |
| GSE19899_A2 | Up | 0.1576081199 |
| PubMed_21979375_A1 | Up | 0.6788191061 |
| PubMed_21979375_A2 | Down | -0.0967554953 |
| GSE35957 | Up | 0.3541457922 |
| GSE36640 | Down | -0.1739099244 |
| GSE54402 | Up | 0.2805231806 |
| GSE9593 | Down | -0.0418843527 |
| GSE43922 | Up | 0.1966961200 |
| GSE24585 | Down | -0.2867634519 |
| GSE37065 | Down | -0.0360433089 |
| GSE28863_A1 | Up | 0.2836173613 |
| GSE28863_A2 | Up | 0.3584117254 |
| GSE28863_A3 | Down | -0.5960051495 |
| GSE28863_A4 | Down | -0.5407400132 |
| GSE48662 | Up | 0.1723512211 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016931 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027020 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030710 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031514 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27358050 | Here we report that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch signalling, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ |
| 27358050 | During and after liver development, the activation of YAP/TAZ induced by loss of Lats1/2 forces hepatoblasts or hepatocytes to commit to the biliary epithelial cell (BEC) lineage |
| 21099353 | Senescence is driven by the activation of PKCalpha, which induces p16(Ink4a)/Rb through a MEK-dependent downregulation of Id1, and PKCdelta, which downregulates Lats1/Warts, a mitotic exit network kinase required for cytokinesis |
| 19927127 | Cells that constitutively express NUAK1 suffer gross aneuploidies and show diminished expression of the genomic stability regulator LATS1, whereas depletion of NUAK1 with shRNA exerts opposite effects |
| 19927127 | Interestingly, a dominant-negative form of LATS1 phenocopies NUAK1 effects |
| 19927127 | Moreover, we show that NUAK1 phosphorylates LATS1 at S464 and this has a role in controlling its stability |
| 17028578 | Sustained activation of ROS-PKCdelta signalling irreversibly blocks cytokinesis, at least partly through reducing the level of WARTS (also known as LATS1), a mitotic exit network (MEN) kinase required for cytokinesis, in human senescent cells |
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