HCSGD entry for USP10
1. General information
| Official gene symbol | USP10 |
|---|---|
| Entrez ID | 9100 |
| Gene full name | ubiquitin specific peptidase 10 |
| Other gene symbols | UBPO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0004197 | Cysteine-type endopeptidase activity | IMP | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0010506 | Regulation of autophagy | IDA | biological_process |
| GO:0016579 | Protein deubiquitination | IDA IMP | biological_process |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | IMP | biological_process |
| GO:0044325 | Ion channel binding | IDA | molecular_function |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1063132822 | 0.8347180768 | 0.6775476755 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1788422891 |
| GSE13712_SHEAR | Up | 0.3462810040 |
| GSE13712_STATIC | Up | 0.2311654629 |
| GSE19018 | Up | 0.0103859591 |
| GSE19899_A1 | Up | 0.0945374400 |
| GSE19899_A2 | Up | 0.4369734526 |
| PubMed_21979375_A1 | Up | 0.5026457706 |
| PubMed_21979375_A2 | Down | -0.0470138800 |
| GSE35957 | Down | -0.1770837640 |
| GSE36640 | Down | -0.3512928707 |
| GSE54402 | Up | 0.1436504054 |
| GSE9593 | Up | 0.3403647526 |
| GSE43922 | Up | 0.4032844997 |
| GSE24585 | Down | -0.0920408549 |
| GSE37065 | Down | -0.0868628338 |
| GSE28863_A1 | Up | 0.2256887282 |
| GSE28863_A2 | Up | 0.2916633188 |
| GSE28863_A3 | Down | -0.0974156268 |
| GSE28863_A4 | Up | 0.1087086999 |
| GSE48662 | Down | -0.4846585538 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019670 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022173 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023247 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027416 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030377 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032235 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037849 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039563 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047239 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049080 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050557 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
