HCSGD entry for USP14
1. General information
| Official gene symbol | USP14 |
|---|---|
| Entrez ID | 9097 |
| Gene full name | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
| Other gene symbols | TGT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000502 | Proteasome complex | IEA | cellular_component |
| GO:0004197 | Cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | TAS | molecular_function |
| GO:0004866 | Endopeptidase inhibitor activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007268 | Synaptic transmission | IEA | biological_process |
| GO:0008193 | TRNA guanylyltransferase activity | TAS | molecular_function |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010466 | Negative regulation of peptidase activity | IMP | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IMP | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | IMP | biological_process |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0050790 | Regulation of catalytic activity | IMP | biological_process |
| GO:0050920 | Regulation of chemotaxis | IMP | biological_process |
| GO:0052547 | Regulation of peptidase activity | IMP | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | IMP | biological_process |
| GO:0061136 | Regulation of proteasomal protein catabolic process | IMP | biological_process |
| GO:0070628 | Proteasome binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9154906387 | 0.0642694085 | 0.9999902473 | 0.4779980503 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0270051962 |
| GSE13712_SHEAR | Down | -0.1265589662 |
| GSE13712_STATIC | Up | 0.0821232177 |
| GSE19018 | Down | -0.3857282218 |
| GSE19899_A1 | Down | -0.5335534137 |
| GSE19899_A2 | Down | -0.4649016565 |
| PubMed_21979375_A1 | Up | 0.1273341362 |
| PubMed_21979375_A2 | Down | -0.6341270421 |
| GSE35957 | Down | -0.0869808918 |
| GSE36640 | Up | 0.1555545364 |
| GSE54402 | Up | 0.0215915701 |
| GSE9593 | Up | 0.1296131139 |
| GSE43922 | Down | -0.0924676085 |
| GSE24585 | Down | -0.4785549412 |
| GSE37065 | Down | -0.0581926119 |
| GSE28863_A1 | Up | 0.1320444794 |
| GSE28863_A2 | Up | 0.4650945037 |
| GSE28863_A3 | Down | -0.1831664293 |
| GSE28863_A4 | Up | 0.0999309947 |
| GSE48662 | Down | -0.7147886943 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024696 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026381 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029168 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT047022 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052341 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052527 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
