HCSGD entry for PAPSS2
1. General information
| Official gene symbol | PAPSS2 |
|---|---|
| Entrez ID | 9060 |
| Gene full name | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| Other gene symbols | ATPSK2 BCYM4 SK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000103 | Sulfate assimilation | IEA | biological_process |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0004020 | Adenylylsulfate kinase activity | IEA | molecular_function |
| GO:0004781 | Sulfate adenylyltransferase (ATP) activity | IEA ISS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0016779 | Nucleotidyltransferase activity | ISS | molecular_function |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | TAS | biological_process |
| GO:0050428 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | TAS | biological_process |
| GO:0060348 | Bone development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1379950116 | 0.0848902739 | 0.7482832097 | 0.5529906258 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0681697197 |
| GSE13712_SHEAR | Up | 0.6051342664 |
| GSE13712_STATIC | Up | 0.2393870235 |
| GSE19018 | Up | 0.4814971884 |
| GSE19899_A1 | Down | -0.3792092962 |
| GSE19899_A2 | Up | 0.1455952113 |
| PubMed_21979375_A1 | Up | 0.0320616937 |
| PubMed_21979375_A2 | Down | -0.1807738893 |
| GSE35957 | Down | -0.2236658202 |
| GSE36640 | Up | 0.9757512109 |
| GSE54402 | Up | 0.0090068696 |
| GSE9593 | Up | 0.6369884935 |
| GSE43922 | Down | -0.1761795939 |
| GSE24585 | Down | -0.8408438436 |
| GSE37065 | Down | -0.2196033950 |
| GSE28863_A1 | Up | 0.3404367353 |
| GSE28863_A2 | Up | 0.2548012604 |
| GSE28863_A3 | Down | -1.0850326678 |
| GSE28863_A4 | Up | 0.1632279496 |
| GSE48662 | Down | -0.7900387528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002636 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002636 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050720 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26250908 | We found that depletion of 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2), a synthetic enzyme of the sulfur donor PAPS, led to premature cell senescence in various cancer cells and in a xenograft tumor mouse model |
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