HCSGD entry for PRC1
1. General information
| Official gene symbol | PRC1 |
|---|---|
| Entrez ID | 9055 |
| Gene full name | protein regulator of cytokinesis 1 |
| Other gene symbols | ASE1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000022 | Mitotic spindle elongation | TAS | biological_process |
| GO:0000226 | Microtubule cytoskeleton organization | IEA | biological_process |
| GO:0000910 | Cytokinesis | IDA IEA | biological_process |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005876 | Spindle microtubule | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008017 | Microtubule binding | IEA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9523911440 | 0.0000059800 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.6593448454 |
| GSE13712_SHEAR | Down | -1.0165281127 |
| GSE13712_STATIC | Down | -0.8302465578 |
| GSE19018 | Up | 0.1886740155 |
| GSE19899_A1 | Down | -4.4690299695 |
| GSE19899_A2 | Down | -5.3763061930 |
| PubMed_21979375_A1 | Down | -3.8281471853 |
| PubMed_21979375_A2 | Down | -6.6719346015 |
| GSE35957 | Down | -4.7028479350 |
| GSE36640 | Down | -5.1318455966 |
| GSE54402 | Down | -1.7895815886 |
| GSE9593 | Down | -2.2586875680 |
| GSE43922 | Down | -3.5886919865 |
| GSE24585 | Up | 0.0232328711 |
| GSE37065 | Down | -0.8428732827 |
| GSE28863_A1 | Down | -0.2800857047 |
| GSE28863_A2 | Up | 0.2750846954 |
| GSE28863_A3 | Up | 0.2853503325 |
| GSE28863_A4 | Up | 0.3376718501 |
| GSE48662 | Down | -1.9960658833 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002532 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-548b-3p | MIMAT0003254 | MIRT016238 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT040993 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049644 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052746 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25505268 | Here, we report that the polo-like kinase 1 (PLK1) regulates BMI1 expression, and that its inhibition can efficiently down-regulate BMI1 expression and PRC1 activity, and induce premature senescence in breast cancer cells |
| 25505268 | Thus, our data suggest that PLK1 inhibitors can be successfully used to inhibit growth of tumors in which PcG protein BMI1 is overexpressed or the PRC1 activity is deregulated |
| 25406515 | Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription factor NF-YA to either promote or suppress senescence |
| 24485159 | Mammalian cells encode multiple permutations of the prototypic Polycomb repressive complex 1 (PRC1) with little evidence for functional specialization |
| 24485159 | PCR-based validation at representative loci suggests that a further six PRC1 proteins have similar binding patterns |
| 24485159 | Importantly, sequential chromatin immunoprecipitation with antibodies against different orthologs implies that multiple variants of PRC1 associate with the same DNA |
| 24485159 | Interestingly, the PRC1 binding profiles are preserved in senescent cells despite changes in gene expression |
| 24485159 | CONCLUSIONS: The multiple permutations of PRC1 in human fibroblasts congregate at common rather than specific sites in the genome and with overlapping but distinctive binding profiles in different fibroblasts |
| 24485159 | The data imply that the effects of PRC1 complexes on gene expression are more subtle than simply repressing the loci at which they bind |
| 22025288 | PRC1 (Pombe repressor complex (1) and PRC2 (Pombe repressor complex (2) proteins and histone deacetylases play an important role in the promoter hypermethylation for suppressing p16 expression |
| 21197464 | JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27) |
| 21059868 | The Polycomb group of proteins forms at least two distinct complexes designated the Polycomb repressive complex-1 (PRC1) and PRC2 |
| 21059868 | Pcl2, however, exhibits a profound synergistic effect on PRC1-mediated Hox repression, which is not accompanied by major alterations in the local trimethylation of histone H3 at lysine 27 (H3K27me3) or PRC1 deposition |
| 21059868 | Pcl2 therefore functions in collaboration with both PRC2 and PRC1 to repress Hox gene expression during axial development |
| 21059868 | We therefore propose a novel role for Pcl2 to modify functional engagement of PRC2 and PRC1, which could be modulated by sensing cellular circumstances |
| 20950777 | JDP2 inhibits recruitment of the polycomb repressive complexes 1 and 2 (PRC-1 and PRC-2) to the promoter of the gene that encodes p16(Ink4a) and inhibits the methylation of lysine 27 of histone H3 (H3K27) |
| 20808772 | Levels of both Zfp277 and PcG proteins inversely correlated with those of reactive oxygen species (ROS) in senescing MEFs, but the treatment of Zfp277(-/-) MEFs with an antioxidant restored the binding of PRC2 but not PRC1 to the Ink4a/Arf locus |
| 20808772 | CONCLUSIONS/SIGNIFICANCE: Our findings implicate Zfp277 in the transcriptional regulation of the Ink4a/Arf locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus |
| 19636380 | Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene |
| 19636380 | Sequential chromatin immunoprecipitation (ChIP) reveals that CBX7 and CBX8 bind simultaneously to the same region of chromatin and knockdown of one of the Pc or Psc proteins results in release of the other, suggesting that the binding of PRC1 complexes is interdependent |
| 19636380 | Our findings provide the first evidence that a single gene can be regulated by several distinct PRC1 complexes and raise important questions about their configuration and relative functions |
| 18332116 | SWI/SNF mediates eviction of the PRC1 and PRC2 PcG silencers and extensive chromatin reprogramming |
Entries Per Page
Displaying Page of
