HCSGD entry for BMF
1. General information
| Official gene symbol | BMF |
|---|---|
| Entrez ID | 90427 |
| Gene full name | Bcl2 modifying factor |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001669 | Acrosomal vesicle | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0016459 | Myosin complex | IEA ISS | cellular_component |
| GO:0032464 | Positive regulation of protein homooligomerization | IEA ISS | biological_process |
| GO:0043276 | Anoikis | IDA | biological_process |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IEA ISS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | biological_process |
| GO:2001234 | Negative regulation of apoptotic signaling pathway | IEA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0428821321 | 0.6517474640 | 0.4616283320 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1290292740 |
| GSE13712_SHEAR | Down | -1.4884025632 |
| GSE13712_STATIC | Down | -0.5291785315 |
| GSE19018 | Up | 0.1646056716 |
| GSE19899_A1 | Up | 0.2108983661 |
| GSE19899_A2 | Up | 0.6928337686 |
| PubMed_21979375_A1 | Down | -0.2545666256 |
| PubMed_21979375_A2 | Up | 0.9035163302 |
| GSE35957 | Up | 0.1036323167 |
| GSE36640 | Down | -0.1793386001 |
| GSE54402 | Up | 0.6082074767 |
| GSE9593 | Down | -0.2628425319 |
| GSE43922 | Up | 0.2455435169 |
| GSE24585 | Up | 1.0125345349 |
| GSE37065 | Up | 0.1741159968 |
| GSE28863_A1 | Up | 0.1380683178 |
| GSE28863_A2 | Up | 0.0223941065 |
| GSE28863_A3 | Up | 0.3134310582 |
| GSE28863_A4 | Up | 0.0483751829 |
| GSE48662 | Down | -0.1900406831 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT000141 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19671867 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT003394 | immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 19471102 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot} | {overexpression} | 19671867 | |
| hsa-miR-125b-5p | MIMAT0000423 | 2 | hsa-miR-125b | {Western blot} | {overexpression} | 19471102 | |
| hsa-miR-125b-5p | MIMAT0000423 | 1 | hsa-miR-125b | {Western blot} | {overexpression} | 19471102 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22932806 | Dyskeratosis congenita is characterized by a mucocutaneous triad, bone marrow failure (BMF), and presence of short telomeres because of mutations in telomerase |
| 22932806 | Allelic variations in TRF1 have been found associated with BMF |
| 22932806 | To address a possible role for TRF1 dysfunction in BMF, here we generated a mouse model with conditional TRF1 deletion in the hematopoietic system |
| 22932806 | Together, these results represent proof of principle that mutations in TRF1 lead to the main clinical features of BMF |
| 19572808 | During childhood, most FA patients display progressive bone marrow failure (BMF), the mechanism of which has not been clarified to date |
| 19572808 | However, FA MSCs showed reduced long-term proliferation ability, higher stem cell factor and interleukin-6 levels, and increased expression of senescent-associated beta-galactosidase compared to normal MSCs, suggesting a potential role of the BM microenvironment in long-term BMF |
Entries Per Page
Displaying Page of
