HCSGD entry for SEMA5A

1. General information

Official gene symbolSEMA5A
Entrez ID9037
Gene full namesema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Other gene symbolsSEMAF semF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationISSbiological_process
GO:0002043Blood vessel endothelial cell proliferation involved in sprouting angiogenesisISSbiological_process
GO:0005886Plasma membraneTAScellular_component
GO:0007155Cell adhesionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008046Axon guidance receptor activityIEAmolecular_function
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0021536Diencephalon developmentISSbiological_process
GO:0030215Semaphorin receptor bindingISSmolecular_function
GO:0030836Positive regulation of actin filament depolymerizationISSbiological_process
GO:0034260Negative regulation of GTPase activityIMPbiological_process
GO:0035373Chondroitin sulfate proteoglycan bindingISSmolecular_function
GO:0035413Positive regulation of catenin import into nucleusISSbiological_process
GO:0043395Heparan sulfate proteoglycan bindingISSmolecular_function
GO:0045545Syndecan bindingISSmolecular_function
GO:0045766Positive regulation of angiogenesisISSbiological_process
GO:0048842Positive regulation of axon extension involved in axon guidanceISSbiological_process
GO:0048843Negative regulation of axon extension involved in axon guidanceISSbiological_process
GO:0051897Positive regulation of protein kinase B signalingISSbiological_process
GO:0060326Cell chemotaxisISSbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processISSbiological_process
GO:2001028Positive regulation of endothelial cell chemotaxisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25236739870.02284062920.94232041130.2907099613

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5585064525
GSE13712_SHEARDown-0.0164331320
GSE13712_STATICUp0.0093524358
GSE19018Up0.0645200112
GSE19899_A1Down-0.4150690857
GSE19899_A2Down-1.2057322554
PubMed_21979375_A1Down-1.7222614647
PubMed_21979375_A2Down-0.9593857668
GSE35957Up0.8327391281
GSE36640Down-1.0713348502
GSE54402Up0.1892257687
GSE9593Up1.1486608335
GSE43922Down-0.3306445553
GSE24585Down-0.0374893079
GSE37065Down-0.1846925633
GSE28863_A1Up0.5738934136
GSE28863_A2Up1.1678433440
GSE28863_A3Down-0.4722733571
GSE28863_A4Down-0.2335874828
GSE48662Up0.1174047865

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030970MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.