HCSGD entry for WASL

1. General information

Official gene symbolWASL
Entrez ID8976
Gene full nameWiskott-Aldrich syndrome-like
Other gene symbolsN-WASP NWASP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEAmolecular_function
GO:0005083Small GTPase regulator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006461Protein complex assemblyTASbiological_process
GO:0006900Membrane buddingISSbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008154Actin polymerization or depolymerizationTASbiological_process
GO:0009617Response to bacteriumIEAbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleISScellular_component
GO:0016050Vesicle organizationISSbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0030050Vesicle transport along actin filamentISSbiological_process
GO:0030478Actin capIEAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0032880Regulation of protein localizationIEAbiological_process
GO:0034629Cellular protein complex localizationIEAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046209Nitric oxide metabolic processTASbiological_process
GO:0050999Regulation of nitric-oxide synthase activityTASbiological_process
GO:0051491Positive regulation of filopodium assemblyISSbiological_process
GO:0051653Spindle localizationIEAbiological_process
GO:2000370Positive regulation of clathrin-mediated endocytosisISSbiological_process
GO:2000601Positive regulation of Arp2/3 complex-mediated actin nucleationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03482386690.97377467800.42611991641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3811704330
GSE13712_SHEARUp0.0454236768
GSE13712_STATICDown-0.1048572909
GSE19018Up0.0112900629
GSE19899_A1Up0.1234069613
GSE19899_A2Up0.4595438505
PubMed_21979375_A1Up0.7612064580
PubMed_21979375_A2Up0.6058632178
GSE35957Up0.1793101944
GSE36640Up0.4636389001
GSE54402Up0.3293810162
GSE9593Up0.5015199836
GSE43922Up0.1475187525
GSE24585Up0.1094692353
GSE37065Up0.0247684312
GSE28863_A1Up0.2314847313
GSE28863_A2Up0.4138866575
GSE28863_A3Down-0.0599069528
GSE28863_A4Down-0.3031631204
GSE48662Up0.0923547708

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049810CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051048CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051960CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.