HCSGD entry for CCND3
1. General information
| Official gene symbol | CCND3 |
|---|---|
| Entrez ID | 896 |
| Gene full name | cyclin D3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000307 | Cyclin-dependent protein kinase holoenzyme complex | IDA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0042098 | T cell proliferation | IEA | biological_process |
| GO:0045737 | Positive regulation of cyclin-dependent protein kinase activity | IDA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5814013259 | 0.2944733787 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4513180445 |
| GSE13712_SHEAR | Up | 0.1350005941 |
| GSE13712_STATIC | Up | 0.2678649871 |
| GSE19018 | Down | -0.1971268143 |
| GSE19899_A1 | Down | -0.6309389789 |
| GSE19899_A2 | Up | 0.0957100895 |
| PubMed_21979375_A1 | Down | -0.3735957900 |
| PubMed_21979375_A2 | Down | -0.1767557547 |
| GSE35957 | Down | -0.1640605236 |
| GSE36640 | Up | 0.6631860888 |
| GSE54402 | Up | 0.0434358550 |
| GSE9593 | Down | -0.1434185312 |
| GSE43922 | Down | -0.0927765611 |
| GSE24585 | Down | -0.3208656059 |
| GSE37065 | Up | 0.0219833191 |
| GSE28863_A1 | Down | -0.0742603870 |
| GSE28863_A2 | Up | 0.2359975226 |
| GSE28863_A3 | Up | 0.0374084190 |
| GSE28863_A4 | Down | -0.1447462594 |
| GSE48662 | Up | 0.1983208100 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT000937 | qRT-PCR//flow//Luciferase reporter assay//Western blot | Functional MTI | 18701644 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT000940 | qRT-PCR//flow//Luciferase reporter assay//Western blot | Functional MTI | 18701644 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT001010 | Western blot | Non-Functional MTI | 18406353 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT006246 | Luciferase reporter assay//Western blot | Functional MTI | 22217655 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT006299 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22362728 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039712 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043067 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046238 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052181 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | {Western blot} | {overexpression} | 18701644 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23079655 | Ablation of cyclin D3 in mice bearing Notch1-driven T cell acute lymphoblastic leukemias (T-ALL) triggered tumor cell apoptosis |
| 19433493 | PTTG1 activates cyclin D3 and represses p21 expression, indicating a role in cell cycle regulation and cell senescence |
| 17519288 | In HeLa cells, RNAi-induced downregulation of BAF significantly increased the proportion of early S-phase cells that retained high levels of cyclin D3 and cyclin E expression and slowed progression through early S phase |
| 1409718 | To determine if expression of human D-type cyclin genes correlates with the state of cell growth, we examined the level of mRNAs for CCND1 and a related gene, CCND3, in normal human diploid fibroblasts (HDF) |
| 1409718 | Cycloheximide partially blocks the induction of CCND1 and CCND3 gene expression by serum, suggesting that both de novo protein synthesis-dependent and -independent pathways contribute to induction |
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