HCSGD entry for BTRC

1. General information

Official gene symbolBTRC
Entrez ID8945
Gene full namebeta-transducin repeat containing E3 ubiquitin protein ligase
Other gene symbolsBETA-TRCP FBW1A FBXW1 FBXW1A FWD1 bTrCP bTrCP1 betaTrCP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIEAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008013Beta-catenin bindingIEAmolecular_function
GO:0016032Viral processTASbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019005SCF ubiquitin ligase complexIDAcellular_component
GO:0030163Protein catabolic processIEAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031648Protein destabilizationIMPbiological_process
GO:0033598Mammary gland epithelial cell proliferationIEAbiological_process
GO:0042753Positive regulation of circadian rhythmIEAbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0045309Protein phosphorylated amino acid bindingIEAmolecular_function
GO:0045862Positive regulation of proteolysisIMPbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0061136Regulation of proteasomal protein catabolic processIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03144833020.97530458570.40998093121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1228571454
GSE13712_SHEARUp0.0456709503
GSE13712_STATICUp0.1681541612
GSE19018Up0.1237541529
GSE19899_A1Up0.1866163365
GSE19899_A2Up0.6962660544
PubMed_21979375_A1Up0.4109878648
PubMed_21979375_A2Up0.9456182959
GSE35957Up0.1479904184
GSE36640Up1.2636814019
GSE54402Up0.0234593139
GSE9593Up0.1660745166
GSE43922Up0.5788740085
GSE24585Down-0.1650559987
GSE37065Up0.1211980363
GSE28863_A1Up0.1448202804
GSE28863_A2Up0.1948391771
GSE28863_A3Down-0.5884905591
GSE28863_A4Up0.0325390922
GSE48662Up0.1148499755

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-183-5pMIMAT0000261MIRT0046735'RACE//qRT-PCR//Western blotFunctional MTI19647520
hsa-miR-10a-5pMIMAT0000253MIRT005510Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20624982
hsa-miR-193b-3pMIMAT0002819MIRT016603MicroarrayFunctional MTI (Weak)20304954
hsa-miR-320aMIMAT0000510MIRT044652CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049068CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051304CLASHFunctional MTI (Weak)23622248
hsa-miR-15a-5pMIMAT0000068MIRT051351CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051452CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-183-5pMIMAT00002611hsa-miR-183{Western blot}{downregulation by anti-miRNA oligonucleotide}19647520
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21430439Here, we report that BMI1 contains a functional recognition motif for the F box protein betaTrCP, which regulates ubiquitination and proteasome-mediated degradation of various proteins
21430439We show that overexpression of wild-type betaTrCP but not the DeltaF mutant of it promotes BMI1 ubiquitination and degradation, and knockdown of betaTrCP results in increased expression of BMI1
21430439Furthermore, a mutant of BMI1 with an altered betaTrCP recognition motif is much more stable than wild-type BMI1
21430439We also show that wild-type BMI1 but not the mutant BMI1 interacts with betaTrCP
21430439In summary, our findings suggest that betaTrCP regulates turnover of BMI1 and its function relevant to oncogenesis, cellular senescence and aging
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