HCSGD entry for KYNU

1. General information

Official gene symbolKYNU
Entrez ID8942
Gene full namekynureninase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006569Tryptophan catabolic processIEA IMP TASbiological_process
GO:0009435NAD biosynthetic processIEAbiological_process
GO:0019441Tryptophan catabolic process to kynurenineIEAbiological_process
GO:0019442Tryptophan catabolic process to acetyl-CoAIEAbiological_process
GO:0019805Quinolinate biosynthetic processIDAbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0030429Kynureninase activityIDA IEA IMP TASmolecular_function
GO:0034341Response to interferon-gammaIDAbiological_process
GO:0034516Response to vitamin B6IMPbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043420Anthranilate metabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0097053L-kynurenine catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00002093390.82528388360.01490638301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2342772930
GSE13712_SHEARUp1.0704279308
GSE13712_STATICUp1.4787858359
GSE19018Down-0.4489304863
GSE19899_A1Up3.0576626812
GSE19899_A2Up4.2971144344
PubMed_21979375_A1Up5.9390193362
PubMed_21979375_A2Up5.7635108409
GSE35957Down-1.9065279281
GSE36640Up2.7702632692
GSE54402Up2.3240854626
GSE9593Down-0.1753343736
GSE43922Up4.5938583687
GSE24585Up0.3470340641
GSE37065Up1.4360334705
GSE28863_A1Up0.0118232394
GSE28863_A2Down-0.3190353579
GSE28863_A3Up0.2368867086
GSE28863_A4Down-0.0434128616
GSE48662Down-0.1590686817

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-AlanineDB00160 NUTR00013
3-Hydroxyhippuric acidDB07069 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.