HCSGD entry for MBD4
1. General information
| Official gene symbol | MBD4 |
|---|---|
| Entrez ID | 8930 |
| Gene full name | methyl-CpG binding domain protein 4 |
| Other gene symbols | MED1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000737 | DNA catabolic process, endonucleolytic | TAS | biological_process |
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003696 | Satellite DNA binding | TAS | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004520 | Endodeoxyribonuclease activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | IEA TAS | biological_process |
| GO:0006285 | Base-excision repair, AP site formation | TAS | biological_process |
| GO:0007095 | Mitotic G2 DNA damage checkpoint | IEA | biological_process |
| GO:0008263 | Pyrimidine-specific mismatch base pair DNA N-glycosylase activity | IDA | molecular_function |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
| GO:0009314 | Response to radiation | IEA | biological_process |
| GO:0045008 | Depyrimidination | TAS | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6852429163 | 0.2984024391 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0538943345 |
| GSE13712_SHEAR | Down | -0.1603169015 |
| GSE13712_STATIC | Down | -0.1854031243 |
| GSE19018 | Up | 0.0814873651 |
| GSE19899_A1 | Up | 0.1976084444 |
| GSE19899_A2 | Down | -0.1103875984 |
| PubMed_21979375_A1 | Up | 0.4530670947 |
| PubMed_21979375_A2 | Up | 0.2277340999 |
| GSE35957 | Down | -0.0103124871 |
| GSE36640 | Down | -0.3746899114 |
| GSE54402 | Up | 0.1597748709 |
| GSE9593 | Down | -0.4633492007 |
| GSE43922 | Up | 0.2684570278 |
| GSE24585 | Up | 0.1483154502 |
| GSE37065 | Up | 0.0340690500 |
| GSE28863_A1 | Down | -0.0723112335 |
| GSE28863_A2 | Up | 0.1091673393 |
| GSE28863_A3 | Down | -0.8015022739 |
| GSE28863_A4 | Down | -0.1933417671 |
| GSE48662 | Down | -0.0627077400 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-205-5p | MIMAT0000266 | 3 | hsa-miR-205 | {Western blot} | {endogenous} | 20065103 | |
| hsa-miR-205-5p | MIMAT0000266 | 1 | hsa-miR-205 | {Western blot} | {endogenous} | 20065103 | |
| hsa-miR-205-5p | MIMAT0000266 | 2 | hsa-miR-205 | {Western blot} | {endogenous} | 20065103 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
