HCSGD entry for BCL10

1. General information

Official gene symbolBCL10
Entrez ID8915
Gene full nameB-cell CLL/lymphoma 10
Other gene symbolsCARMEN CIPER CLAP c-E10 mE10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001772Immunological synapseIEAcellular_component
GO:0001783B cell apoptotic processIEAbiological_process
GO:0001843Neural tube closureISSbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayICbiological_process
GO:0002237Response to molecule of bacterial originIEPbiological_process
GO:0002250Adaptive immune responseTASbiological_process
GO:0002906Negative regulation of mature B cell apoptotic processIDAbiological_process
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005881Cytoplasmic microtubuleIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006968Cellular defense responseIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008219Cell deathIDAbiological_process
GO:0009620Response to fungusIEAbiological_process
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0019209Kinase activator activityIDAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019900Kinase bindingIPImolecular_function
GO:0019901Protein kinase bindingIDAmolecular_function
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032094Response to foodIDAbiological_process
GO:0032449CBM complexNAScellular_component
GO:0032765Positive regulation of mast cell cytokine productionNASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0042109Lymphotoxin A biosynthetic processNASbiological_process
GO:0042226Interleukin-6 biosynthetic processNASbiological_process
GO:0042327Positive regulation of phosphorylationIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043422Protein kinase B bindingIPImolecular_function
GO:0043621Protein self-associationIPImolecular_function
GO:0045087Innate immune responseIEP TASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045416Positive regulation of interleukin-8 biosynthetic processIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046696Lipopolysaccharide receptor complexIDAcellular_component
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050852T cell receptor signaling pathwayIDA TASbiological_process
GO:0050856Regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050870Positive regulation of T cell activationIEAbiological_process
GO:0051059NF-kappaB bindingIDAmolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051259Protein oligomerizationIPIbiological_process
GO:0051260Protein homooligomerizationISS TASbiological_process
GO:0070231T cell apoptotic processIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14198036550.85945793850.75654840081.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2270149931
GSE13712_SHEARUp0.5310544862
GSE13712_STATICUp0.3756266478
GSE19018Down-0.1212400100
GSE19899_A1Up0.1092249194
GSE19899_A2Up0.0387157089
PubMed_21979375_A1Up0.1793071788
PubMed_21979375_A2Down-0.2915391553
GSE35957Up0.2244231340
GSE36640Up0.0623929791
GSE54402Up0.0778125558
GSE9593Up0.0138194974
GSE43922Up0.2166031612
GSE24585Up0.2801321350
GSE37065Up0.1790440160
GSE28863_A1Down-0.1402344947
GSE28863_A2Up0.4346728451
GSE28863_A3Down-0.4252100756
GSE28863_A4Down-0.1817661553
GSE48662Up0.0397091117

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-340-5pMIMAT0004692MIRT019608SequencingFunctional MTI (Weak)20371350
hsa-miR-375MIMAT0000728MIRT019968MicroarrayFunctional MTI (Weak)20215506
hsa-miR-33a-5pMIMAT0000091MIRT028199SequencingFunctional MTI (Weak)20371350
hsa-miR-100-5pMIMAT0000098MIRT048426CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22658522Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-kappaB
22658522The adaptor protein Bcl10 is a critically important mediator of T cell receptor (TCR)-to-NF-kappaB signaling
22658522Bcl10 degradation is a poorly understood biological phenomenon suggested to reduce TCR activation of NF-kappaB
22658522Here we have shown that TCR engagement triggers the degradation of Bcl10 in primary effector T cells but not in naive T cells
22658522Bcl10 autophagy was highly selective, as shown by the fact that it spared Malt1, a direct Bcl10 binding partner
22658522Blockade of Bcl10 autophagy enhanced TCR activation of NF-kappaB
22658522Together, these data demonstrate that selective autophagy of Bcl10 is a pathway-intrinsic homeostatic mechanism that modulates TCR signaling to NF-kappaB in effector T cells
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