HCSGD entry for CCNB1

1. General information

Official gene symbolCCNB1
Entrez ID891
Gene full namecyclin B1
Other gene symbolsCCNB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000922Spindle poleIDAcellular_component
GO:0000942Condensed nuclear chromosome outer kinetochoreIDAcellular_component
GO:0001556Oocyte maturationIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIEAbiological_process
GO:0005113Patched bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006461Protein complex assemblyIEAbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007077Mitotic nuclear envelope disassemblyTASbiological_process
GO:0007080Mitotic metaphase plate congressionIMPbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0019901Protein kinase bindingIEA IPImolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031442Positive regulation of mRNA 3'-end processingIEAbiological_process
GO:0033129Positive regulation of histone phosphorylationIEAbiological_process
GO:0042246Tissue regenerationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043148Mitotic spindle stabilizationIMPbiological_process
GO:0045931Positive regulation of mitotic cell cycleIMPbiological_process
GO:0046680Response to DDTIEAbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051987Positive regulation of attachment of spindle microtubules to kinetochoreIMPbiological_process
GO:0055015Ventricular cardiac muscle cell developmentIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060623Regulation of chromosome condensationIEAbiological_process
GO:0071174Mitotic spindle checkpointIMPbiological_process
GO:0071283Cellular response to iron(III) ionIEAbiological_process
GO:0071398Cellular response to fatty acidIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98551316060.00000869270.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.2740109893
GSE13712_SHEARDown-0.5597508704
GSE13712_STATICDown-0.5558873096
GSE19018Down-0.0155234431
GSE19899_A1Down-2.7516584787
GSE19899_A2Down-3.2663072708
PubMed_21979375_A1Down-3.8162867202
PubMed_21979375_A2Down-5.2787201091
GSE35957Down-4.8228657713
GSE36640Down-3.7066419777
GSE54402Down-1.1563479658
GSE9593Down-1.6918349504
GSE43922Down-1.7549778048
GSE24585Down-0.1226262170
GSE37065Down-0.7382307224
GSE28863_A1Down-0.7038632424
GSE28863_A2Up0.9502263448
GSE28863_A3Down-0.4675177924
GSE28863_A4Up0.2319686257
GSE48662Down-1.4149027793

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021866Western blot;qRT-PCRFunctional MTI21329664
hsa-miR-212-3pMIMAT0000269MIRT024969Western blot;qRT-PCRFunctional MTI21329664
hsa-miR-24-3pMIMAT0000080MIRT030588MicroarrayFunctional MTI (Weak)19748357
hsa-miR-183-5pMIMAT0000261MIRT047127CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049477CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050578CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051879CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26476078Growth suppression was mediated by G1 blockade involving increased p21 expression and suppressed cyclin B1, CDK1, and CDC25C
23574719Furthermore, levels of the G1-specific markers, Cyclin D1 and Caveolin-1, were distinctly increased, while S/G2-specific markers, Cyclin B1 and Aurora A, were significantly downregulated
23095053S100A6 depletion also decreased expression of CDK1, cyclin A1 (CCNA1) and cyclin B (CCNB1) genes with effects on cell-cycle progression
20222868A decrease in cyclin B1 levels leads to polyploidization in DNA damage-induced senescence
20222868We wished, therefore, to explore the role of cyclin B1 level in polyploidization of Adriamycin-induced senescent cells
20222868In DNA damage-induced senescent cells, the levels of cyclin B1 were transiently increased and subsequently decreased
20222868The decrease in cyclin B1 levels occurred in G2 cells during polyploidization upon treatment with a subcytotoxic concentration of Adriamycin
20222868In contrast, neither polyploidy nor a decrease in cyclin B1 levels was induced by treatment with a cytotoxic concentration of Adriamycin
20222868These results suggest that a decrease in cyclin B1 levels is induced by DNA damage, resulting in polyploidization in DNA damage-induced senescence
18031612The expressions of p21 and p53 was upregulated with PAB treatment, and cyclin B1 was upregulated and transported from the cytoplasm to nuclei, and sustained stable levels
11642719The expressions of Rb, Ki67, cyclin A and cyclin B1 were overlapping, being high in the cortex with a tendency for decreased expression toward the medulla
11642719The mean values of Ki67, cyclin A, and cyclin B1 expression in thymuses were 77
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