HCSGD entry for CCNA1
1. General information
| Official gene symbol | CCNA1 |
|---|---|
| Entrez ID | 8900 |
| Gene full name | cyclin A1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007141 | Male meiosis I | TAS | biological_process |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0011452110 | 0.9951856844 | 0.0906312312 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2195927888 |
| GSE13712_SHEAR | Up | 3.3822021590 |
| GSE13712_STATIC | Up | 3.6581338810 |
| GSE19018 | Up | 0.2135232240 |
| GSE19899_A1 | Up | 0.2041149014 |
| GSE19899_A2 | Up | 0.2801507623 |
| PubMed_21979375_A1 | Up | 0.4118361888 |
| PubMed_21979375_A2 | Up | 0.7410137260 |
| GSE35957 | Down | -0.0848407135 |
| GSE36640 | Down | -0.0345287281 |
| GSE54402 | Up | 0.9628050258 |
| GSE9593 | Up | 0.3603515084 |
| GSE43922 | Up | 0.7479360308 |
| GSE24585 | Up | 1.7523156275 |
| GSE37065 | Up | 0.0563055989 |
| GSE28863_A1 | Down | -0.0366139506 |
| GSE28863_A2 | Down | -0.0221469198 |
| GSE28863_A3 | Up | 0.1511795658 |
| GSE28863_A4 | Up | 0.0124315818 |
| GSE48662 | Down | -0.0012694754 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018229 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022823 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032444 | Reporter assay | Non-Functional MTI | 18379589 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23095053 | S100A6 depletion also decreased expression of CDK1, cyclin A1 (CCNA1) and cyclin B (CCNB1) genes with effects on cell-cycle progression |
| 22258036 | Furthermore, DNA methylation levels of genes related to development of most or all tumor types, such as BRCA1, CCNA1, CDKN2A (p16), THBS1, TNFRSF10C and TNFRSF10D, were increased in BPA-exposed HMEC |
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