HCSGD entry for CCNA2
1. General information
| Official gene symbol | CCNA2 |
|---|---|
| Entrez ID | 890 |
| Gene full name | cyclin A2 |
| Other gene symbols | CCN1 CCNA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IEA | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001939 | Female pronucleus | IEA | cellular_component |
| GO:0001940 | Male pronucleus | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007095 | Mitotic G2 DNA damage checkpoint | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | IEP | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0033762 | Response to glucagon | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0048146 | Positive regulation of fibroblast proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9978704570 | 0.0000064663 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.7927206468 |
| GSE13712_SHEAR | Down | -0.2298307249 |
| GSE13712_STATIC | Down | -0.3454645233 |
| GSE19018 | Down | -0.0330971100 |
| GSE19899_A1 | Down | -2.1864986058 |
| GSE19899_A2 | Down | -4.3809477532 |
| PubMed_21979375_A1 | Down | -4.2860930767 |
| PubMed_21979375_A2 | Down | -6.7792756393 |
| GSE35957 | Down | -3.3558020597 |
| GSE36640 | Down | -3.9750370271 |
| GSE54402 | Down | -1.3840011132 |
| GSE9593 | Down | -2.5027839210 |
| GSE43922 | Down | -3.2442619946 |
| GSE24585 | Down | -0.2957684383 |
| GSE37065 | Down | -0.9434460815 |
| GSE28863_A1 | Down | -0.5683564176 |
| GSE28863_A2 | Up | 0.0170560699 |
| GSE28863_A3 | Down | -0.4012353537 |
| GSE28863_A4 | Down | -0.0360982419 |
| GSE48662 | Down | -1.6058214598 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT000119 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Other | Functional MTI | 19748357 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT003999 | Immunoblot//Immunofluorescence//Luciferase reporter assay//qRT-PCR | Functional MTI | 18379589 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT004017 | Microarray//qRT-PCR//Western blot | Functional MTI | 19944095 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016556 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021865 | Western blot;qRT-PCR | Functional MTI | 21329664 |
| hsa-miR-212-3p | MIMAT0000269 | MIRT024968 | Western blot;qRT-PCR | Functional MTI | 21329664 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027829 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048136 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | NA | hsa-miR-145 | 19996289 | |||
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 | |||
| hsa-miR-24-3p | MIMAT0000080 | 1 | hsa-miR-24 | 19748357 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 24 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25364077 | Senescence markers showed reduced TERT and cyclin A and increased p16INK4a expression, with higher IL-6 plasma levels in SF-exposed mice |
| 25040935 | This PIM-1-mediated HP1gamma phosphorylation enhanced HP1gamma's capacity to bind to H3K9me3, resulting in heterochromatin formation and suppression of proliferative genes, such as CCNA2 and PCNA |
| 24445253 | Interaction of SAMHD1 with cyclin A was assessed by coimmunoprecipitation and fluorescence cross-correlation spectroscopy |
| 23811199 | The suppressed expression of cyclin A2 and B1 and the concomitant induction of p21(Waf1) were evident in SOD1-KO cells |
| 22955272 | The retinoblastoma (Rb) protein mediates heterochromatin formation at the promoters of E2 transcription factor 1 (E2F1) target genes, such as proliferating cell nuclear antigen and cyclin A2 (CCNA2), and represses these genes during cellular senescence |
| 22955272 | By comparing the promoter sequences of these genes, we found a novel TAAC element that is present in the cellular senescence-inhibited gene, proliferating cell nuclear antigen, and CCNA2 promoters but absent from the ARF and p27(KIP1) promoters |
| 21263217 | Moreover, cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition |
| 19648966 | Expression of cyclin A and entry into S-phase resumed after RNA interference-mediated knockdown of Rb2/p130 |
| 18852884 | A significant upregulation of cyclin D1 and reduction of cyclin A was detected in HFF-MBPsi-4 as compared to control HFF |
| 18271016 | Consistent with activation of the pRb proteins, E2F-responsive genes such as cyclin A are repressed in EWS/FLI1-depleted cells |
| 17242207 | Specialized domains of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF), are thought to contribute to the irreversible cell cycle exit in many senescent cells by repressing the expression of proliferation-promoting genes such as cyclin A |
| 16123778 | Maintenance of the arrest depends on the functions of p130(Rb2) repressing cyclin A |
| 12533509 | We further demonstrate that mutant cells that escaped senescence had undergone clonal selection for faster proliferation and extensive genetic/molecular alterations, including overexpression of cyclin D1 and cyclin A and loss of p53 |
| 11791184 | Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis |
| 11791184 | Unscheduled expression of cyclin A in the sub-G0/G1 peak occurred in the IGFBP-rP1/mac25 clones |
| 11791184 | In addition, the appearance of cyclin A in the sub-G0/G1 phase of the cell cycle and the increased kinase activity of cyclin A/cdk-2 in the IGFBP-rP1/mac25 clones suggests that cyclin A is associated with the apoptotic cells |
| 11642719 | The expressions of Rb, Ki67, cyclin A and cyclin B1 were overlapping, being high in the cortex with a tendency for decreased expression toward the medulla |
| 11642719 | The mean values of Ki67, cyclin A, and cyclin B1 expression in thymuses were 77 |
| 10962000 | Adenovirally mediated ectopic overexpression of p27(Kip1) in exponentially growing IGF-I transgenic satellite cells reversed the increase in cyclin E-cdk2 kinase activity, pRb phosphorylation, and cyclin A protein abundance, thereby implicating an important role for p27(Kip1) in promoting satellite cell senescence |
| 10537318 | The disruption of p21 activity affects the p21-Rb-E2F pathway in that the expression of genes transcriptionally regulated by E2F, such as cyclin A and cdc2, were found to be up-regulated in injected cells |
| 8816912 | Western blot analysis showed that among the E2F-associated proteins, the expression of E2F-1, cyclin A, and cyclin B but not p107 was cell cycle- and senescence-dependent |
| 8853893 | Addition of purified p21 protein to the S-phase-specific cyclin A/ CDK2-p107-E2F complex from young cells dissociated cyclin A and CDK2 from p107/E2F, suggesting an additional novel function for p21 |
| 7542356 | The RT-PCR and Western blot analyses have shown that in senescent TIG-1 cells at PDL64-67, cdk2 and cyclin E were selectively repressed at the mRNA and protein levels even after serum stimulation, and cdc2 and cyclin A were less repressed than cdk2 and cyclin E |
| 7510251 | Consistent with the latter observation we found that cyclin A, which is required for cells to traverse through S to G2, was downregulated in these cells |
| 8262140 | In contrast, cdk2 and cyclin A mRNAs were completely down-regulated in stimulated senescent fibroblasts, while the G1 cyclins, C, D1, and E mRNAs, were still expressed in stimulated senescent cells although at reduced levels compared to young cells |
| 8262140 | We investigated whether transfection of cyclin A, alone or in combination with cdc2, was sufficient for extension of lifespan or escape from senescence |
| 8262140 | Clones expressing the transfected human cyclin A or cdc2 genes senesced at a population doubling similar to controls, thereby showing that cyclin A or cdc2 expression alone was insufficient for escape from senescence |
| 8248208 | Amounts of cyclin A, which ordinarily accumulates in S and G2 phases, were extremely low in stimulated senescent cells |
| 8248208 | We suggest that the failure to activate cyclin E-Cdk2 kinase activity in senescent cells may account for the inability of these cells to phosphorylate the retinoblastoma protein in late G1 phase, which in turn may block the expression of late G1 genes such as cyclin A that are required for entry into S phase |
| 8360268 | It has previously been shown that three cell cycle genes, cyclin A, cyclin B and cdc2, are not expressed in senescent human fibroblasts |
| 1297331 | We find that cyclin A and p34cdc2 expression is decreased by two- to four-fold in old fibroblasts, but that Fos expression and binding activity are reduced by as much as 95% in old, as opposed to young cells, despite equivalent amounts of p105Rb and Jun proteins being expressed |
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