HCSGD entry for EIF2B2
1. General information
| Official gene symbol | EIF2B2 |
|---|---|
| Entrez ID | 8892 |
| Gene full name | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa |
| Other gene symbols | EIF-2Bbeta EIF2B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001541 | Ovarian follicle development | IMP | biological_process |
| GO:0003743 | Translation initiation factor activity | IDA | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005851 | Eukaryotic translation initiation factor 2B complex | IDA | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IDA TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IBA TAS | biological_process |
| GO:0007417 | Central nervous system development | IMP | biological_process |
| GO:0009408 | Response to heat | ISS TAS | biological_process |
| GO:0009749 | Response to glucose | ISS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0014003 | Oligodendrocyte development | IMP | biological_process |
| GO:0019509 | L-methionine salvage from methylthioadenosine | IBA | biological_process |
| GO:0042552 | Myelination | IMP | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA IMP | biological_process |
| GO:0043434 | Response to peptide hormone | ISS | biological_process |
| GO:0044237 | Cellular metabolic process | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0046523 | S-methyl-5-thioribose-1-phosphate isomerase activity | IBA | molecular_function |
| GO:0051716 | Cellular response to stimulus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0707867102 | 0.2522835683 | 0.5682966504 | 0.9643270113 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5706553733 |
| GSE13712_SHEAR | Up | 0.4285567033 |
| GSE13712_STATIC | Up | 0.1992706843 |
| GSE19018 | Down | -0.6077305522 |
| GSE19899_A1 | Up | 0.8107225910 |
| GSE19899_A2 | Down | -0.0938586757 |
| PubMed_21979375_A1 | Up | 0.8879854378 |
| PubMed_21979375_A2 | Up | 0.4332080785 |
| GSE35957 | Down | -0.4398071000 |
| GSE36640 | Down | -0.8530210948 |
| GSE54402 | Up | 0.4299875466 |
| GSE9593 | Down | -0.7322854692 |
| GSE43922 | Up | 0.2874232139 |
| GSE24585 | Down | -0.1159342710 |
| GSE37065 | Down | -0.0555969382 |
| GSE28863_A1 | Down | -0.1461452396 |
| GSE28863_A2 | Down | -0.0947200149 |
| GSE28863_A3 | Down | -0.4745874545 |
| GSE28863_A4 | Up | 0.1727573709 |
| GSE48662 | Up | 0.0064200570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020527 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031428 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037833 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040533 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049061 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
