HCSGD entry for EIF2B4

1. General information

Official gene symbolEIF2B4
Entrez ID8890
Gene full nameeukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Other gene symbolsEIF-2B EIF2B EIF2Bdelta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001541Ovarian follicle developmentIMPbiological_process
GO:0003743Translation initiation factor activityIDA IEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationIDA TASbiological_process
GO:0006417Regulation of translationNASbiological_process
GO:0006446Regulation of translational initiationIBAbiological_process
GO:0009408Response to heatISS TASbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014003Oligodendrocyte developmentIMPbiological_process
GO:0019509L-methionine salvage from methylthioadenosineIBAbiological_process
GO:0031369Translation initiation factor bindingISSmolecular_function
GO:0032057Negative regulation of translational initiation in response to stressISSbiological_process
GO:0042552MyelinationIMPbiological_process
GO:0043087Regulation of GTPase activityIDA IMPbiological_process
GO:0043434Response to peptide hormoneISSbiological_process
GO:0044237Cellular metabolic processIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045947Negative regulation of translational initiationIBAbiological_process
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBAmolecular_function
GO:0051716Cellular response to stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05243732760.89359050950.50087202471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7447670796
GSE13712_SHEARDown-0.1418771439
GSE13712_STATICUp0.0298807473
GSE19018Down-0.3246911624
GSE19899_A1Up0.2793279349
GSE19899_A2Up0.4064892061
PubMed_21979375_A1Up0.9199176543
PubMed_21979375_A2Up0.7043616898
GSE35957Down-0.2424925522
GSE36640Up0.3234550695
GSE54402Up0.3296709787
GSE9593Down-0.0563932494
GSE43922Up0.2120739671
GSE24585Down-0.5356064784
GSE37065Up0.0905543301
GSE28863_A1Up0.1344906762
GSE28863_A2Up0.2675564499
GSE28863_A3Down-0.0296257099
GSE28863_A4Down-0.0077765015
GSE48662Down-0.0244903503

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028435ProteomicsFunctional MTI (Weak)18668040
hsa-miR-196a-5pMIMAT0000226MIRT048246CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.