HCSGD entry for KRIT1

1. General information

Official gene symbolKRIT1
Entrez ID889
Gene full nameKRIT1, ankyrin repeat containing
Other gene symbolsCAM CCM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIMPbiological_process
GO:0005083Small GTPase regulator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0010596Negative regulation of endothelial cell migrationIMPbiological_process
GO:0016525Negative regulation of angiogenesisIEA IMPbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0043234Protein complexIEAcellular_component
GO:0045454Cell redox homeostasisIEA IMPbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:2000114Regulation of establishment of cell polarityIEA IMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79814596710.19487905470.99999024730.8553733167

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0166885838
GSE13712_SHEARUp0.1351367162
GSE13712_STATICUp0.0207691376
GSE19018Down-0.1826960361
GSE19899_A1Down-0.2454143033
GSE19899_A2Down-0.1306959307
PubMed_21979375_A1Down-0.0503116512
PubMed_21979375_A2Down-0.2695869228
GSE35957Down-0.0749302638
GSE36640Down-0.0417150980
GSE54402Down-0.3353926096
GSE9593Up0.1366685605
GSE43922Down-0.0699071309
GSE24585Up0.3518821494
GSE37065Up0.1148163867
GSE28863_A1Up0.1405923904
GSE28863_A2Up0.5595038368
GSE28863_A3Down-0.5054330864
GSE28863_A4Down-0.3647789361
GSE48662Up0.0524129936

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.