HCSGD entry for NAE1
1. General information
| Official gene symbol | NAE1 |
|---|---|
| Entrez ID | 8883 |
| Gene full name | NEDD8 activating enzyme E1 subunit 1 |
| Other gene symbols | A-116A10.1 APPBP1 ula-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0019781 | NEDD8 activating enzyme activity | IDA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033314 | Mitotic DNA replication checkpoint | IDA | biological_process |
| GO:0042981 | Regulation of apoptotic process | IDA | biological_process |
| GO:0043523 | Regulation of neuron apoptotic process | IDA | biological_process |
| GO:0045116 | Protein neddylation | IDA IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0051402 | Neuron apoptotic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0345366096 | 0.8516010410 | 0.4261199164 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3361338010 |
| GSE13712_SHEAR | Down | -0.0796065968 |
| GSE13712_STATIC | Up | 0.1498113067 |
| GSE19018 | Up | 0.5217625080 |
| GSE19899_A1 | Up | 0.4115444130 |
| GSE19899_A2 | Up | 0.4515608379 |
| PubMed_21979375_A1 | Up | 0.6683692008 |
| PubMed_21979375_A2 | Up | 0.3451694206 |
| GSE35957 | Down | -0.0713418214 |
| GSE36640 | Down | -0.1375553206 |
| GSE54402 | Up | 0.7142362053 |
| GSE9593 | Down | -0.2161704707 |
| GSE43922 | Up | 0.1623328079 |
| GSE24585 | Down | -0.5063674129 |
| GSE37065 | Up | 0.0226231862 |
| GSE28863_A1 | Up | 0.0076932055 |
| GSE28863_A2 | Up | 0.3913938529 |
| GSE28863_A3 | Down | -0.5705384862 |
| GSE28863_A4 | Up | 0.3031412071 |
| GSE48662 | Down | -0.1987731982 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029193 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030401 | Microarray | Functional MTI (Weak) | 19748357 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24853380 | Compared with lung adenocarcinoma patients with low expression, those with high expression had worse overall survival (NEDD8-activating enzyme E1 subunit 1 [NAE1]: hazard ratio [HR] = 2 |
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