HCSGD entry for SQSTM1

1. General information

Official gene symbolSQSTM1
Entrez ID8878
Gene full namesequestosome 1
Other gene symbolsA170 OSIL PDB3 ZIP3 p60 p62 p62B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000407Pre-autophagosomal structureIEAcellular_component
GO:0000932Cytoplasmic mRNA processing bodyIDAcellular_component
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0002376Immune system processIEAbiological_process
GO:0004674Protein serine/threonine kinase activityNASmolecular_function
GO:0005080Protein kinase C bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005770Late endosomeIEAcellular_component
GO:0005776Autophagic vacuoleIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0006914AutophagyIMP TASbiological_process
GO:0006950Response to stressTASbiological_process
GO:0008104Protein localizationTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016197Endosomal transportTASbiological_process
GO:0016235AggresomeIEAcellular_component
GO:0016236MacroautophagyISSbiological_process
GO:0016310PhosphorylationNASbiological_process
GO:0019901Protein kinase bindingIDAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030971Receptor tyrosine kinase bindingTASmolecular_function
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0046578Regulation of Ras protein signal transductionNASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0070530K63-linked polyubiquitin bindingIEAmolecular_function
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00073739220.99502187230.07733166021.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2501353588
GSE13712_SHEARUp0.6105367716
GSE13712_STATICUp0.5587935099
GSE19018Down-0.0229422073
GSE19899_A1Up0.3334926523
GSE19899_A2Up1.0307795679
PubMed_21979375_A1Up0.7618396965
PubMed_21979375_A2Up1.6626064340
GSE35957Up0.4233620426
GSE36640Up0.6874236944
GSE54402Up0.4220279924
GSE9593Up1.0278856975
GSE43922Up0.5136036563
GSE24585Up0.5929432184
GSE37065Up0.3479250160
GSE28863_A1Up0.0657948269
GSE28863_A2Up0.7294002735
GSE28863_A3Down-0.3762703459
GSE28863_A4Down-0.2752718327
GSE48662Up0.5105006932

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001410pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT018399MicroarrayFunctional MTI (Weak)18185580
hsa-miR-7-5pMIMAT0000252MIRT025851MicroarrayFunctional MTI (Weak)19073608
hsa-miR-877-5pMIMAT0004949MIRT037277CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038085CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042028CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26986194Unexpectedly, the basal autophagic activity was higher in the aged kidney than that in young kidney; short-term cessation of autophagy in tamoxifen-inducible proximal tubule-specific autophagy-deficient mice increased the accumulation of SQSTM1/p62- and ubiquitin-positive aggregates in the aged kidney
26391655Tissue-specific deletion of the essential autophagy gene Atg7 in murine VSMCs (atg7-/- VSMCs) caused accumulation of SQSTM1/p62 and accelerated the development of stress-induced premature senescence as shown by cellular and nuclear hypertrophy, CDKN2A-RB-mediated G1 proliferative arrest and senescence-associated GLB1 activity
26391655Transfection of SQSTM1-encoding plasmid DNA in Atg7+/+ VSMCs induced similar features, suggesting that accumulation of SQSTM1 promotes VSMC senescence
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