HCSGD entry for SPHK1

1. General information

Official gene symbolSPHK1
Entrez ID8877
Gene full namesphingosine kinase 1
Other gene symbolsSPHK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDA ISSmolecular_function
GO:0001568Blood vessel developmentIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0001956Positive regulation of neurotransmitter secretionIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003951NAD+ kinase activityIEAmolecular_function
GO:0004143Diacylglycerol kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006670Sphingosine metabolic processIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008481Sphinganine kinase activityIDAmolecular_function
GO:0009267Cellular response to starvationIEAbiological_process
GO:0010803Regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0014075Response to amineIEAbiological_process
GO:0017050D-erythro-sphingosine kinase activityIDAmolecular_function
GO:0019371Cyclooxygenase pathwayIEAbiological_process
GO:0019722Calcium-mediated signalingIDAbiological_process
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0030335Positive regulation of cell migrationIDA IEAbiological_process
GO:0030424AxonIEAcellular_component
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0032026Response to magnesium ionIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032651Regulation of interleukin-1 beta productionIEAbiological_process
GO:0033198Response to ATPIEAbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIMPbiological_process
GO:0043066Negative regulation of apoptotic processIDA IEA TASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIDAbiological_process
GO:0045987Positive regulation of smooth muscle contractionIDAbiological_process
GO:0046521Sphingoid catabolic processNASbiological_process
GO:0046834Lipid phosphorylationIDAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0051721Protein phosphatase 2A bindingIPImolecular_function
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00105799170.13624746020.08769465410.7115929776

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7415743538
GSE13712_SHEARUp1.3915380083
GSE13712_STATICUp0.7566963500
GSE19018Down-0.2698277593
GSE19899_A1Up0.9448256735
GSE19899_A2Up2.8070029900
PubMed_21979375_A1Up2.5158874887
PubMed_21979375_A2Up2.3566622293
GSE35957Down-1.7144234022
GSE36640Down-2.3179269849
GSE54402Up1.5954837276
GSE9593Down-1.4777358341
GSE43922Up1.7878581300
GSE24585Up0.9971409102
GSE37065Down-0.2453056789
GSE28863_A1Down-0.2548618950
GSE28863_A2Up0.1098088960
GSE28863_A3Up0.0454404975
GSE28863_A4Up0.0596959910
GSE48662Down-0.0073234651

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022271MicroarrayFunctional MTI (Weak)18668037
hsa-miR-484MIMAT0002174MIRT041985CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21765468Defining a role for sphingosine kinase 1 in p53-dependent tumors
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