HCSGD entry for IER3

1. General information

Official gene symbolIER3
Entrez ID8870
Gene full nameimmediate early response 3
Other gene symbolsDIF-2 DIF2 GLY96 IEX-1 IEX-1L IEX1 PRG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001562Response to protozoanIEAbiological_process
GO:0003085Negative regulation of systemic arterial blood pressureIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006282Regulation of DNA repairIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007095Mitotic G2 DNA damage checkpointIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0045820Negative regulation of glycolysisIEAbiological_process
GO:0046822Regulation of nucleocytoplasmic transportIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:1901029Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIEAbiological_process
GO:2000377Regulation of reactive oxygen species metabolic processIEAbiological_process
GO:2001020Regulation of response to DNA damage stimulusIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00227527830.58318114810.12793106381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2420295444
GSE13712_SHEARUp0.0765181141
GSE13712_STATICDown-0.5122664759
GSE19018Up0.0295077429
GSE19899_A1Up1.7136049971
GSE19899_A2Up1.5620083902
PubMed_21979375_A1Up1.5078171359
PubMed_21979375_A2Up1.6338529222
GSE35957Up0.0053189895
GSE36640Down-0.2271894938
GSE54402Up0.4863038834
GSE9593Down-0.4409652352
GSE43922Up1.5931028560
GSE24585Up0.1748222425
GSE37065Up0.6674934614
GSE28863_A1Down-0.1638455229
GSE28863_A2Up0.7028228951
GSE28863_A3Up0.4516670520
GSE28863_A4Down-0.3430025130
GSE48662Up0.3996353777

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004200MicroarrayFunctional MTI (Weak)16822819
hsa-miR-98-5pMIMAT0000096MIRT027607MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.